国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (13): 2237-2241.DOI: 10.3760/cma.j.cn441417-20250318-13025

• 中医药研究 • 上一篇    下一篇

麻杏石甘汤合过敏煎加味联合常规西医治疗咳嗽变异性哮喘患儿的临床效果

倪莉 韩改琳   

  1. 咸阳市中心医院儿内科,咸阳 712000

  • 收稿日期:2025-03-18 出版日期:2025-07-01 发布日期:2025-08-04
  • 通讯作者: 韩改琳,Email:455438331@qq.com
  • 基金资助:

    陕西省自然科学基础研究计划(2022JQ-794)

Clinical efficacy of modified Maxing Shigan decoction combined with anti-allergic decoction plus conventional western medicine in the treatment of children with cough variant asthma

Ni Li, Han Gailin   

  1. Department of Pediatrics, Xianyang Central Hospital, Xianyang 712000, China

  • Received:2025-03-18 Online:2025-07-01 Published:2025-08-04
  • Contact: Han Gailin, Email:455438331@qq.com
  • Supported by:

    Natural Science Fundamental Research Plan of Shaanxi(2022JQ-794)

摘要:

目的 探讨麻杏石甘汤合过敏煎加味与常规西医治疗联合应用于咳嗽变异性哮喘儿童的临床效果。方法 采用前瞻性研究方法,选取2021年1月至2024年1月咸阳市中心医院儿内科175例诊断为咳嗽变异性哮喘的儿童,使用随机数字表法分为治疗组和对照组。对照组86例中男50例,女36例,年龄(8.31±2.55)岁;治疗组89例中男52例,女37例,年龄(8.26±2.59)岁。对照组口服孟鲁司特钠咀嚼片,2~5岁儿童每晚睡前服用4 mg咀嚼片,6~15岁儿童每晚睡前服用5 mg咀嚼片。治疗组患儿在对照组基础上联合使用麻杏石甘汤合过敏煎加味进行治疗,每日煎药2次,早、晚各服用200 ml。两组均持续治疗4周。比较两组患儿的临床疗效、临床指标、中医证候评分、免疫功能及不良反应发生率。统计学方法采用t检验、χ2检验。结果 治疗组总有效率高于对照组[89.89%(80/89)比69.77%(60/86)],差异有统计学意义(χ2=11.066,P=0.001)。治疗4周后,治疗组的咳痰消退、咳嗽消退、体温恢复、喘息消退时间分别为(4.21±0.89、7.12±1.05、5.51±1.02、4.41±1.24)d,对照组分别为(7.92±0.96、9.33±1.02、7.26±1.11、6.95±1.36)d,差异均有统计学意义(均P<0.001);治疗组的干咳少痰、面色萎黄、气促、多汗、舌淡红、舌薄白或薄黄评分均低于对照组,免疫球蛋白(Ig)G、IgA、IgM水平均高于对照组(均P<0.05)。两组不良反应总发生率差异无统计学意义(χ2=0.132,P=0.715)。结论 麻杏石甘汤合过敏煎加味联合常规西医治疗可以显著改善咳嗽变异性哮喘患儿的临床症状,改善免疫功能,是一种安全有效的治疗方法。

关键词: 咳嗽变异性哮喘, 麻杏石甘汤合过敏煎, 孟鲁司特钠咀嚼片, 免疫功能, 儿童

Abstract:

Objective To investigate the clinical efficacy of modified Maxing Shigan decoction combined with anti-allergic decoction plus conventional Western medicine in the treatment of children with cough variant asthma (CVA). Methods A prospective study was conducted on 175 children diagnosed with CVA who were admitted to the Department of Pediatrics, Xianyang Central Hospital, from January 2021 to January 2024. Using a random number table method, the children were divided into a treatment group and a control group. The control group (n=86) included 50 males and 36 females, aged (8.31±2.55) years; the treatment group (n=89) included 52 boys and 37 girls, aged (8.26±2.59) years. The control group was given oral Montelukast Sodium chewable tablets: children aged 2-5 years took 4 mg once nightly before bedtime, and children aged 6-15 years took 5 mg once nightly before bedtime. The treatment group received modified Maxing Shigan decoction combined with an anti-allergic decoction additionally, with 200 ml administered twice daily (morning and evening) on top of the control group regimen. Both groups received treatment for 4 weeks. The two groups were compared in terms of clinical efficacy, clinical indicators, traditional Chinese medicine (TCM) syndrome scores, immune function, and incidence of adverse reactions. Statistical analysis was performed using t tests and χ² tests. Results The total effective rate in the treatment group was higher than that in the control group [89.89% (80/89) vs. 69.77% (60/86)], with a statistically significant difference (χ²=11.066, P=0.001). After 4 weeks of treatment, the durations for sputum resolution, cough resolution, normalization of body temperature, and resolution of wheezing in the treatment group were (4.21±0.89, 7.12±1.05, 5.51±1.02, 4.41±1.24) d, compared to (7.92±0.96, 9.33±1.02, 7.26±1.11, 6.95±1.36) d in the control group, with statistically significant differences (all P<0.001). The scores for dry cough with little sputum, sallow complexion, shortness of breath, sweating, pale red tongue, and thin white or yellow tongue in the treatment group were lower than those in the control group, while levels of IgG, IgA, and IgM were higher in the treatment group compared to the control group (all P<0.05). The overall incidence of adverse reactions did not differ significantly between the two groups (χ²=0.132, P=0.715). Conclusion Modified Maxing Shigan decoction combined with anti-allergic decoction plus conventional western medicine significantly improves clinical symptoms and immune function in children with CVA, establishing the regimen as a safe and effective treatment method.

Key words: Cough variant asthma,  , Maxing Shigan , decoction combined with anti-allergic decoction,  , Western medicine,  , Clinical effects,  , Immune function,  , Children