关键词:

D-二聚体, 依达拉奉右莰醇, 进展性脑梗死, 病灶面积

Abstract:

Objective　To explore the value of D-dimer level in the prediction of the improvement of lesion area after edaravone dexcamphol for progressive cerebral infarction. Methods　The clinical data of 102 patients with progressive cerebral infarction treated at Zhengzhou Central Hospital, Zhengzhou University from January 2023 to April 2024 were selected as the study objects. According to their prognosis, the patients were divided into a good prognosis group (74 cases) and a poor prognosis group (28 cases). The general data and serum indicators of the two groups were compared. The influence of time on the relationship between the D-dimer level and lesion area was analyzed by the hierarchical interaction test using the EmpowerStats software. The correlation between D-dimer level and adverse prognosis risk was analyzed by the multivariate Cox regression analysis. Results　There were statistical differences in the systolic blood pressure, diabetes, hypertension, atrial fibrillation, hyperlipidemia, D-dimer, uric acid (UA), and score of National Institute of Health Stroke Scale (NIHSS) before the treatment between the good prognosis group and the poor prognosis group (all P<0.05). The levels of D-dimer [(219.43±21.67) g/L vs. (172.88±22.11) g/L, (207.67±22.43) g/L vs. (153.79±22.12) g/L, (184.49±22.08) g/L vs. (122.95±22.11) g/L, and (163.59±22.45) g/L vs. (101.69±22.47) g/L] and the Alberta Stroke Program Early CT Scores (ASPECTS) (1.45±0.46 vs. 2.22±0.45, 2.84±0.44 vs. 4.62±0.43, 3.72±0.47 vs. 5.95±0.51, and 5.02±0.58 vs. 7.52±0.45) on the day when the treatment was finished and 1, 2, and 4 weeks after the treatment in the poor prognosis group were worse than those in the good prognosis group, with statistical differences (all P<0.05). There was a correlation between the level of D-dimer and the change of lesion area at each time point (all P<0.05). According to the D-dimer level triplet, the patients were divided into a low-level group (D-dimer<188.27 g/L; 25 cases), a middle-level group (D-dimer 188.27-241.21 g/L; 54 cases), and a high-level group (D-dimer>241.21 g/L; 23 cases); the high-level group had higher adverse prognosis risk than the other two groups (P<0.05). Conclusion　The level of D-dimer has certain predictive value for the improvement of lesion area after edaravone dexcamphol for progressive cerebral infarction, and can be used as an indicator for clinically monitoring the effect of edaravone dexcamphol for progressive cerebral infarction.

Key words:

D-dimer, Edaravone dexcamphol, Progressive cerebral infarction, Lesion area