解郁疏肝汤加减治疗多囊卵巢综合征（肝郁肾虚证）的效果分析

doi:10.3760/cma.j.cn441417-20250109-12023

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (12): 2046-2051.DOI: 10.3760/cma.j.cn441417-20250109-12023

解郁疏肝汤加减治疗多囊卵巢综合征（肝郁肾虚证）的效果分析

张朝红¹ 刘妍¹ 雷静² 姜丽丽³ 刘兰⁴ 胡雅平³

¹宝鸡市妇幼保健院妇二科，宝鸡 721000；²宝鸡市妇幼保健院妇女保健科，宝鸡 721000；³宝鸡市妇幼保健院生殖中心，宝鸡 721000；⁴宝鸡市妇幼保健院乳腺甲状腺科，宝鸡 721000

收稿日期:2025-01-09 出版日期:2025-06-15 发布日期:2025-06-15
通讯作者: 胡雅平，Email：Huyaping102@163.com
基金资助:
陕西省重点研发计划（2023-YBSF-492）

Effect analysis of Jieyu Shugan Decoction in treating polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome)

Zhang Zhaohong¹, Liu Yan¹, Lei Jing², Jiang Lili³, Liu Lan⁴, Hu Yaping³

¹Second Department of Gynecology,Baoji Maternal and Child Health Hospital, Baoji 721000 ,China; ²Women's Health Care Department ,Gynecology, Baoji Maternal and Child Health Center, Baoji 721000 ,China; ³Reproductive Center ,Baoji Maternal and Child Health Hospital, Baoji 721000 ,China; ⁴Breast and Thyroid Department , Baoji Maternal and Child Health Hospital, Baoji 721000 ,China

Received:2025-01-09 Online:2025-06-15 Published:2025-06-15
Contact: Hu Yaping, Email: Huyaping102@163.com
Supported by:
Shaanxi Provincial Key Research and Development Program(2023-YBSF-492)

摘要/Abstract

摘要：

目的　分析解郁疏肝汤加减治疗多囊卵巢综合征（肝郁肾虚证）的效果。方法　采用回顾性分析方法。选取2022年1月至2023年12月期间宝鸡市妇幼保健院收治的101例多囊卵巢综合征（肝郁肾虚证）患者，按照治疗方法不同将其分为对照组和观察组。对照组50例，年龄（29.67±3.52）岁，病程（3.31±0.64）年；观察组51例，年龄（30.43±3.64）岁，病程（3.48±0.73）年。对照组口服炔雌醇环丙孕酮片，观察组服用炔雌醇环丙孕酮片+解郁疏肝汤加减方。两组均连续治疗12周。比较两组患者的临床疗效、不良反应及治疗前后的中医症候积分、血清激素［促卵泡生成素（FSH）、雌二醇（E2）、黄体生成素（LH）、睾酮（T）、抗苗勒氏管激素（AMH）］水平、子宫内膜容受性［子宫动脉搏动指数（PI）、子宫动脉阻力指数（RI）］。采用t检验、χ2检验进行统计学分析。结果　治疗后，观察组治疗总有效率高于对照组［94.12%（48/51）比78.00%（39/50）］，差异有统计学意义（P<0.05）。观察组中医症候积分、血清LH、T、AMH水平及PI、RI值均低于对照组［（8.61±2.13）分比（14.52±3.27）分、（9.05±1.37）IU/L比（11.16±1.52）IU/L、（0.92±0.17）pmol/L比（1.11±0.23）pmol/L、（7.29±1.14）μg/L比（9.46±1.37）μg/L、2.16±0.26比2.52±0.39、0.62±0.11比0.73±0.10］（t=10.783、12.026、12.534、15.904、5.468、5.256，均P<0.05），血清FSH、E2水平均高于对照组［（5.91±0.61）IU/L比（5.64±0.57）IU/L、（204.62±23.57）ng/L比（165.38±16.82）ng/L］，差异均有统计学意义（均P<0.05）。观察组的不良反应总发生与对照组比较，差异无统计学意义［7.84%（4/51）比10.00%（5/50），P>0.05］。结论　解郁疏肝汤加减治疗多囊卵巢综合征（肝郁肾虚证），可提高治疗效果，减轻症状，调节血清激素水平，改善子宫内膜血流状态，且不会增加不良反应的发生。

关键词: 多囊卵巢综合征, 解郁疏肝汤, 肝郁肾虚证

Abstract:

Objective To analyze the effect of Jieyu Shugan Decoction on polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome). Methods A retrospective analysis was conducted. A total of 101 patients with polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome) admitted to Baoji Maternal and Child Health Hospital during January 2022 to December 2023 were selected and divided into a control group and an observation group based on different treatment methods. The control group received oral cyproterone acetate and ethinyl estradiol tablets, while the observation group received the same tablets plus modified Jieyu Shugan Decoction. The control group consisted of 50 patients with age of (29.67 ± 3.52) years and disease duration of (3.31 ± 0.64) years. The observation group consisted of 51 patients with an average age of (30.43 ± 3.64) years and an average disease duration of (3.48 ± 0.73) years. Both groups were treated continuously for 12 weeks. The clinical efficacy, adverse reactions, and changes in traditional Chinese medicine (TCM) symptom scores, serum hormone levels [follicle stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), testosterone (T), anti-mullerian hormone (AMH)], and uterine artery hemodynamics [pulsatility index (PI) and resistance index (RI)] were compared between the two groups. Statistical analysis was performed using t and χ² tests.Results After treatment, the total effective rate of treatment in the observation group was higher than that in the control group [94.12% (48/51) vs. 78.00% (39/50)], and the difference was statistically significant (P<0.05). The TCM syndrome score, serum LH, T, and AMH levels, PI, and RI in the observation group were all lower than those in the control group [(8.61±2.13) points vs. (14.52±3.27) points, (9.05±1.37) IU/L vs. (11.16±1.52) IU/L, (0.92±0.17) pmol/L vs. (1.11±)] 0.23) pmol/L, (7.29±1.14) μg/L vs. (9.46±1.37) μg/L, 2.16±0.26 vs. 2.52±0.39, 0.62±0.11 vs. 0.73±0.10](t=10.783, 12.026, 12.534, 15.904, 5.468, 5.256, all P<0.05), and the levels of serum FSH and E2 were both higher [(5.91±0.61) IU/L vs. (5.64±0.57) IU/L, (204.62±23.57) ng/L vs. (165.38±16.82) ng/L];the differences were all statistically significant (all P<0.05).The total occurrence of adverse reactions in the observation group showed no statistically significant difference compared with that in the control group [7.84% (4/51) vs. 10.00% (5/50), P>0.05].Conclusion Jieyu Shugan Decoction in the treatment of polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome) can improve the therapeutic effect, alleviate symptoms, regulate serum hormone levels, and improve endometrial blood flow state, without increasing the occurrence of adverse reactions.

Key words: Polycystic ovary syndrome, , Jieyu Shugan , Decoction, , Liver-stagnation and kidney deficiency syndrome

张朝红刘妍雷静姜丽丽刘兰胡雅平. 解郁疏肝汤加减治疗多囊卵巢综合征（肝郁肾虚证）的效果分析 [J]. 国际医药卫生导报, 2025, 31(12): 2046-2051.

Zhang Zhaohong, Liu Yan, Lei Jing, Jiang Lili, Liu Lan, Hu Yaping.

Effect analysis of Jieyu Shugan Decoction in treating polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome) [J]. International Medicine and Health Guidance News, 2025, 31(12): 2046-2051.

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解郁疏肝汤加减治疗多囊卵巢综合征（肝郁肾虚证）的效果分析

Effect analysis of Jieyu Shugan Decoction in treating polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome)

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