广州社区脑梗死高危人群危险因素的膳食纤维干预效果

doi:10.3760/cma.j.cn441417-20241206-14019

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (14): 2383-2388.DOI: 10.3760/cma.j.cn441417-20241206-14019

广州社区脑梗死高危人群危险因素的膳食纤维干预效果

邓兴东¹^，² 赵秋革¹ 黄海彬¹ 杨钦单¹ 魏永刚¹ 徐评议¹^，² 田作军¹

¹广州医科大学附属第一医院神经内科，广州 510120；²新疆医科大学第二附属医院，乌鲁木齐 830017

收稿日期:2024-12-06 出版日期:2025-07-01 发布日期:2025-08-06
通讯作者: 田作军，Email：tianzuojun9@163.com
基金资助:
广州市科技局基础研究计划市校（院）企联合资助项目（2023A03J0349）；十三五国家重点研发计划（2017YFC1310901）

Effects of dietary fiber intervention on risk factors in high-risk population of cerebral infarction in Guangzhou communities

Deng Xingdong^1,2, Zhao Qiuge¹, Huang Haibin¹, Yang Qindan¹, Wei Yonggang¹, Xu Pingyi^1,2, Tian Zuojun¹

¹Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China; ²The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830017, China

Received:2024-12-06 Online:2025-07-01 Published:2025-08-06
Contact: Tian Zuojun, Email: tianzuojun9@163.com
Supported by:
Guangzhou Science and Technology Bureau Basic Research Project Funded by University-Enterprise-Research Institute Collaboration (2023A03J0349); National Key Research and Development Program of the 13th Five-Year Plan (2017YFC1310901)

摘要/Abstract

摘要：

目的　探讨广州社区脑梗死高危人群危险因素的膳食纤维（DF）干预效果。方法　采用前瞻性研究，收集2018年5月至2023年7月广州医科大学附属第一医院神经内科广州本地脑梗死高危人群DF每日摄入不足25 g者203例，男121例、女82例，年龄（69.26±9.50）岁。随机数字表法分为DF添加组（92例）和对照组（111例）。DF添加组在平时饮食的基础上添加魔芋精粉温水冲服，使其日均膳食纤维摄入量达到25～30 g；对照组保持平时日常饮食不变。比较两组患者膳食纤维干预3月前后的收缩压（SBP）、舒张压（DBP）、斑块积分（Crouse评分）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、糖化血红蛋白（HBA1C）的差值（△值）。然后再分为高血压和非高血压及糖尿病和非糖尿病两个亚组，进行分层分析。采用t检验、Mann-Whitney U或Wilcoxon符号秩检验、χ²检验进行统计分析。结果　干预3个月后，DF添加组的△DBP明显低于对照组（Z=-2.412，P=0.016）；其中，非高血压人群膳食纤维添加组△DBP的改善优于对照组（Z=-2.802，P=0.005）；非糖尿病人群△DBP（Z=-2.196，P=0.028）及△HBA1C（Z=-2.216，P=0.027）改善均优于对照组；糖尿病人群DF添加组△HDL优于对照组（Z=-2.545，P=0.011）。结论　DF干预能显著降低非糖尿病和非高血压人群的DBP，上调糖尿病人群的HDL和降低非糖尿病人群的HBA1C。

关键词: 膳食纤维, 脑梗死, 危险因素, 社区研究

Abstract:

Objective　To investigate the interventional effects of dietary fiber (DF) on risk factors in high-risk population of cerebral infarction in Guangzhou communities. Methods　From May 2018 to July 2023, 203 cases of local high-risk cerebral infarction taking less than 25 g of DF per day were prospectively collected from Department of Neurology, the First Affiliated Hospital of Guangzhou Medical University from Guangzhou communities. There were 121 males and 82 females. They were (69.26±9.50) years old. The patients were randomly divided into a DF additional group (92 cases) and a control group (111 cases). The DF additional group drank extra Konjac powder by adding it to warm water on the basis of regular diet, so that their daily DF intake reached 25-30 g per day. The control group kept the usual daily diet unchanged. The systolic pressures (SBP), diastolic pressures (DBP), Crouse score, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and glycosylated hemoglobin (HBA1C) before and 3 months after DF intervention were compared between the two groups (△ values). Then, the patients were further divided into a hypertension group and a non-hypertension group, as well as a diabetes group and a non-diabetes group for hierarchical analyses. t test, Mann-Whitney U test, or Wilcoxon sign rank test , and χ² test were used for the statistical analysis. Results　After 3 months' DF intervention, the △DBP of the intervention group was significantly lower than that of the control group (Z=-2.412; P=0.016). Among them, the improvement of △DBP in the non-hypertensive subgroup was better than that in the control subgroup (Z=-2.802; P=0.005); the △DBP (Z=-2.196; P=0.028) and △HBA1C (Z=-2.216; P=0.027) in the non-diabetic subgroup was better than that in the control group. The △HDL in the diabetic subgroup was better than that in the control subgroup (Z=-2.545; P=0.011). Conclusions　DF intervention can significantly reduce DBP in non-diabetic and non-hypertensive populations, up-regulate HDL in diabetic patients, and down-regulate HBA1C in non-diabetic population.

Key words: Dietary fiber, , Cerebral infarction, , Risk factors, , Community research

邓兴东赵秋革黄海彬杨钦单魏永刚徐评议田作军.

广州社区脑梗死高危人群危险因素的膳食纤维干预效果 [J]. 国际医药卫生导报, 2025, 31(14): 2383-2388.

Deng Xingdong, Zhao Qiuge, Huang Haibin, Yang Qindan, Wei Yonggang, Xu Pingyi, Tian Zuojun.

Effects of dietary fiber intervention on risk factors in high-risk population of cerebral infarction in Guangzhou communities [J]. International Medicine and Health Guidance News, 2025, 31(14): 2383-2388.

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广州社区脑梗死高危人群危险因素的膳食纤维干预效果

Effects of dietary fiber intervention on risk factors in high-risk population of cerebral infarction in Guangzhou communities

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