关键词: 拔牙, 牙槽骨吸收, Osteoset XR医用硫酸钙, 浓缩生长因子纤维蛋白膜

Abstract:

Objective　To analyze the application effect of Osteoset XR medical calcium sulfate combined with concentrated growth factor fibrin (CGF) membrane in the prevention of alveolar bone resorption after tooth extraction. Methods　A total of 63 patients requiring tooth extraction admitted to Baoji Stomatological Hospital from May 2021 to September 2023 were selected and were divided into 2 groups according to the envelope method. There were 31 cases in the control group, including 20 males and 11 females, with an age of (42.86±4.85) years old, tooth extraction sites: 18 cases of maxillary molars and 13 cases of mandibular molars. There were 32 cases in the observation group, including 18 males and 14 females, with an age of (44.06±4.03) years old, tooth extraction sites: 20 cases of maxillary molars and 12 cases of mandibular molars. In the control group, the wound surface was covered with double layers of CGF membrane after tooth extraction, and Osteoset XR medical calcium sulfate was used in addition in the observation group. The wound healing status was evaluated 7 days after treatment. The alveolar bone height, width, and density, pain degree, periodontal indicators, and incidence of complications were analyzed. Statistical analysis was performed using the χ² test, rank sum test, and t test. Results　In the observation group, the grade A [97.50% (28/32)], grade B [12.50% (4/32)], and grade C wound healing [0% (0/32)] 7 days after treatment was superior to the control group {grade A [58.06% (18/31)], grade B [35.48% (11/31)], and grade C wound healing [6.45% (2/31)]} (Z=7.427, P=0.024). Three months after treatment, the alveolar bone height [(6.23±1.21) mm] and width [(4.28±0.81) mm] in the observation group were both higher than those in the control group [(5.46±1.17) mm and (3.71±0.75) mm] (t=2.567, P=0.013; t=2.896, P=0.005). Three months after treatment, the alveolar bone mineral density in the observation group was higher than that in the control group [(1.34±0.25) g/cm² vs. (1.15±0.22) g/cm²] (t=3.168, P=0.002); three days after treatment, the pain score of the observation group was lower than that of the control group [(2.36±0.38) points vs. (4.04±0.39) points] (t=17.318, P<0.001). Three months after treatment, the gingival index (GI) [(0.78±0.12) points], plaque index (PLI) [(1.36±0.27) points], and clinical attachment loss (CAL) [(1.63±0.21) mm] in the observation group were lower than those in the control group [(0.92±0.14) points, (1.85±0.29) points, and (2.36±0.24) mm] (t=4.267, P<0.001; t=6.944, P<0.001; t=12.860, P<0.001). There was no statistically significant difference in the total incidence of complications between the two groups (P>0.05). Conclusion　In patients with alveolar bone defect after tooth extraction, CGF membrane combined with Osteoset XR medical calcium sulfate can effectively accelerate wound healing, improve the height, width, and bone density of alveolar bone, improve the periodontal indexes, and reduce the degree of pain, with good clinical application safety.

Key words: Tooth extraction,  , Alveolar bone resorption,  , Osteoset XR medical calcium sulfate,  , Concentrated growth factor fibrin membrane