关键词:

补肾养血调经汤, 异常子宫出血, 子宫内膜厚度, 凝血功能, 性激素

Abstract:

Objective　To investigate the effect of Bushen Yangxue Tiaojing Tang on endometrial thickness, coagulation function, and serum hormone levels in patients with abnormal uterine bleeding. Methods　This was a prospective study. One hundred patients with abnormal uterine bleeding treated at Yangling Demonstration Zone Hospital from January 2021 to January 2024 were selected as the study objects, and were divided into a control group and an observation group by the random number table method, with 50 cases in each group. There control group were (33.13±7.29) years old; their disease course was (3.79±0.65) years. The observation group were (32.89±7.51) years old; their disease course was (3.83±0.61) years. The control group were conventionally treated with western medicine; in addition, the observation group took Bushen Yangxue Tiaojing Tang. The clinical efficacies, scores of traditional Chinese medicine syndromes, clinically relevant indicators, coagulation function indicators [activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen (FIB)], sex hormone indicators [follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2)], and incidence rates of adverse reactions were compared between the two groups. The statistical methods included t test, χ² test, and rank sum test. Results　The total efficacy in the observation group was higher than that in the control group [98.0% (49/50) vs. 80.0% (40/50)], with a statistical difference (P<0.05). The scores of soreness in the waist and knees, dizziness, hyposexuality, dry mouth and tongue, red tongue with little coating, and deep and thin pulse and the levels of FIB, FSH, LH, and E₂ in the observation group were lower than those in the control group [1.12±0.23 vs. 1.65±0.31, 1.23±0.32 vs. 1.78±0.36, 1.16±0.27 vs. 1.64±0.35, 1.05±0.16 vs. 1.46±0.19, 1.13±0.15 vs. 1.49±0.23, 1.03±0.12 vs. 1.54±0.35, (2.19±0.13) g/L vs. (2.61±0.12) g/L, (14.27±1.45) mIU/L vs. (22.29±2.19) mIU/L, (6.15±1.12) mIU/L vs. (8.28±1.65)mIU/L, (179.23±15.35)ng/L vs. (254.68±20.35)ng/L]; the menstruation period, APTT, and PT in the observation group were shorter than those in the control group [(31.21±3.15) d vs. (44.26±4.19) d, (28.65±3.12) s vs. (30.35±3.26) s, and (14.23±1.35) s vs. (15.68±2.39) s]; the menstruation volume in the observation group was lower than that in the control group [(46.29±10.42) ml vs. (65.15±13.82) ml]; the endometrial thickness in the observation group was smaller than that in the control group [(5.25±0.16) mm vs. (7.05±0.21) mm]; there were statistical differences (all P<0.05). There was no statistical difference in the incidence rate of adverse reactions between the two groups (χ²=0.271; P=0.603). Conclusion　Bushen Yangxue Tiaojing Tang for patients with abnormal uterine bleeding can improve their physical signs, coagulation function, and sex hormone levels, and promote the recovery of menstrual flow, menstrual cycle, and endometrial thickness, and is safe.

Key words:

Bushen Yangxue Tiaojing Tang, Abnormal uterine bleeding, Endometrial thickness, Coagulation function, Sex hormones