International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (2): 199-201.DOI: 10.3760/cma.j.issn.1007-1245.2022.02.013

• Scientific Research • Previous Articles     Next Articles

One case of interstitial pneumonia caused by gefitinib

Sun Chunhua, Guo Xuedan, Xiao Xia, Wang Qi, Hua Hongxia, Zhao Fan, Huang Pei   

  1. Department of Oncology, The Second People's Hospital of Wuxi, Wuxi 214002, China
  • Received:2021-08-25 Online:2022-01-15 Published:2022-03-08
  • Contact: Huang Pei, Email: hp3036@sina.com
  • Supported by:
    Research on Hospital Management Innovation of Jiangsu Provincial Hospital Association (JSYGY-3-2019-11)

吉非替尼导致间质性肺炎及评析

孙春花,过雪丹,肖霞,王琦,华红霞,赵帆,黄培   

  1. 南京医科大学附属无锡第二医院肿瘤科,无锡 214002
  • 通讯作者: 黄培,Email:hp3036@sina.com
  • 基金资助:
    江苏省医院协会医院管理创新研究课题(JSYGY-3-2019-11)

Abstract: A 67-year-old male patient took 250 mg gefitinib daily because of epidermal growth factor receptor (EGFR) gene 21 exon mutation in lung cancer. Three months later, the patient developed cough, shortness of breath, and high fever. The chest computerized tomography (CT) suggested pneumonia, and anti-infection treatment was ineffective. After that, gefitinib was discontinued, and oxygen inhalation, intravenous drip of glucocorticoids, liver protection and other treatments were given. His symptoms were significantly relieved one week later.

Key words: Gefitinib, Interstitial pneumonia, Adverse drug reactions

摘要: 1例67岁男性患者因“肺癌,表皮生长因子受体(epidermal growth factor receptor,EGFR) 基因21外显子突变”服用吉非替尼每天250 mg,3个月后出现咳嗽、气急、高热,胸部计算机化断层显像(computerized tomography,CT)提示肺炎,予抗感染治疗无效,后予停服吉非替尼,予吸氧、静脉滴注糖皮质激素、保肝等治疗,1周后症状明显缓解。

关键词: 吉非替尼, 间质性肺炎, 药物不良反应