Research progress of miR-181 in ophthalmic diseases

doi:10.3760/cma.j.issn.1007-1245.2022.23.021

Abstract

Abstract: MicroRNA-181 (miR-181) family members are a group of highly conserved non-coding small molecule RNAs. With the deepening of research, it has been confirmed that they can participate in various signaling pathways that regulate various pathophysiological processes, and affect the proliferation, differentiation, and apoptosis of cells and tissues. In this paper, the action mechanism of miR-181 and the research status of ophthalmic diseases are mainly described, so as to provide references for further research on ophthalmic diseases and treatment.

Key words: MiR-181, Ophthalmic diseases, Retinopathy, Lens epithelial cells

摘要： microRNA-181（miR-181）家族成员是一组高度保守的非编码RNA小分子，随着研究的深入，证实其能够参与调节多种病理生理过程的多种信号通路，进而影响细胞及组织的增殖、分化及凋亡。本文主要针对miR-181的作用机制及在眼科疾病中的研究现况进行阐述，为进一步眼科疾病及治疗的研究提供可借鉴的参考依据。

关键词: miR-181, 眼科疾病, 视网膜病变, 晶状体上皮细胞

Fu Qianfang, Li Shiyi, Zhang Peipei, Xie Yingbin. Research progress of miR-181 in ophthalmic diseases[J]. International Medicine and Health Guidance News, 2022, 28(23): 3342-.

扶乾芳李诗怡张培培谢迎宾. miR-181在眼科疾病中的研究进展[J]. 国际医药卫生导报, 2022, 28(23): 3342-.

References

[1] Lagos-Quintana M,Rauhut R,Lendeckel W,et al.Identification of novel genes coding for small expressed RNAs[J].Science,2001,294(5543): 853-858.DOI:10.1126/science.1064921.
[2] Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.DOI:10.1016/0092-8674(93)90529-y.
[3] Saliminejad K,Khorram Khorshid HR,Soleymani Fard S,et al.An overview of microRNAs: biology, functions, therapeutics, and analysis methods[J].J Cell Physiol,2019,234(5):5451-5465.DOI:10.1002/jcp.27486.
[4] Yang Z,Wan X,Gu Z,et al.Evolution of the mir-181 microRNA family[J].Comput Biol Med,2014,52:82-87.DOI:10.1016/j.compbiomed.2014.06.004.
[5] Ji J,Yamashita T,Budhu A,et al.Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells[J].Hepatology,2009,50(2):472-480.DOI:10.1002/hep.22989.
[6] Yuan R,Liu N,Yang J,et al.The expression and role of miR-181a in multiple myeloma[J].Medicine (Baltimore),2018,97(35):e12081.DOI:10.1097/MD.0000000000012081.
[7] Tang D,Gao W,Yang J,et al.miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma[J].Mol Med Rep,2020,22(5):3804-3812.DOI:10.3892/mmr.2020.11464.
[8] Shi Z,Su Y,Wang F,et al.Downregulation of microRNA-181a attenuates hydrogen peroxide-induced human lens epithelial cell apoptosis in vitro[J].Mol Med Rep,2018,17(4):6009-6015.DOI:10.3892/mmr.2018.8608.
[9] Wei H,Wang J,Xu Z,et al.Hepatoma cell-derived extracellular vesicles promote liver cancer metastasis by inducing the differentiation of bone marrow stem cells through microRNA-181d-5p and the FAK/Src pathway[J].Front Cell Dev Biol,2021,9:607001.DOI:10.3389/fcell.2021.607001.
[10] Lin Y,Zhao J,Wang H,et al.miR-181a modulates proliferation, migration and autophagy in AGS gastric cancer cells and downregulates MTMR3[J].Mol Med Rep,2017,15(5):2451-2456.DOI:10.3892/mmr.2017.6289.
[11] Li L,Ye D,Liu L,et al.Long noncoding RNA SNHG7 accelerates proliferation, migration and invasion of non-small cell lung cancer cells by suppressing miR-181a-5p through AKT/mTOR signaling pathway[J].Cancer Manag Res,2020,12:8303-8312.DOI:10.2147/CMAR.S258487.
[12] Li JG,Ding Y,Huang YM,et al.FAMLF is a target of miR-181b in burkitt lymphoma[J].Braz J Med Biol Res,2017,50(6):e5661.DOI:10.1590/1414-431X20175661.
[13] Zhao L,Li Y,Song X,et al.Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia[J].Oncotarget,2016,7(37):60074-60086.DOI:10.18632/oncotarget.11054.
[14] Sun X,Sit A,Feinberg MW.Role of miR-181 family in regulating vascular inflammation and immunity[J].Trends Cardiovasc Med,2014,24(3):105-112.DOI:10.1016/j.tcm.2013.09.002.
[15] Zhang C,Bo C,Guo L,et al.BCL2 and hsa-miR-181a-5p are potential biomarkers associated with papillary thyroid cancer based on bioinformatics analysis[J].World J Surg Oncol,2019,17(1):221.DOI:10.1186/s12957-019-1755-9.
[16] Wan J,Long F,Zhang C,et al.miR181bp53 negative feedback axis regulates osteosarcoma cell proliferation and invasion[J].Int J Mol Med,2020,45(6):1803-1813.DOI:10.3892/ijmm.2020.4558.
[17] Wang XF,Shi ZM,Wang XR,et al.MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2[J].J Cancer Res Clin Oncol,2012,138(4):573-584.DOI:10.1007/s00432-011-1114-x.
[18] Guo X,Zhu Y,Hong X,et al.miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer[J].Cell Death Dis,2017,8(7):e2958.DOI:10.1038/cddis.2017.300.
[19] Hu J,Huang Y,Lin Y,et al.Protective effect inhibiting the expression of miR-181a on the diabetic corneal nerve in a mouse model[J].Exp Eye Res,2020,192:107925.DOI:10.1016/j.exer.2020.107925.
[20] Sun J,Ma Q,Li B,et al.RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/beta-catenin signaling pathway[J].Cell Death Dis,2020,11(10):890.DOI:10.1038/s41419-020-03113-5.
[21] Ding X,Xu X,He XF,et al.Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation,invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling[J].Bioengineered,2021,12(1):803-814.DOI:10.1080/21655979.2021.1890383.
[22] Panoutsopoulou K,Avgeris M,Magkou P,et al.miR-181a overexpression predicts the poor treatment response and early-progression of serous ovarian cancer patients[J].Int J Cancer,2020,147(12):3560-3573.DOI:10.1002/ijc.33182.
[23] Wang X,Meng Q,Qiao W,et al.miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC[J].Stem Cell Res Ther,2018,9(1):327.DOI:10.1186/s13287-018-1072-1.
[24] Yang F,Liu X,Liu Y,et al.miR-181d/MALT1 regulatory axis attenuates mesenchymal phenotype through NF-kappaB pathways in glioblastoma[J].Cancer Lett,2017,396:1-9.DOI:10.1016/j.canlet.2017.03.002.
[25] Rezaei T,Amini M,Hashemi ZS,et al.microRNA-181 serves as a dual-role regulator in the development of human cancers[J].Free Radic Biol Med,2020,152:432-454.DOI:10.1016/j.freeradbiomed.2019.12.043.
[26] Abu-Farha M,Cherian P,Al-Khairi I,et al.Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3[J].Sci Rep,2019,9(1):11866.DOI:10.1038/s41598-019-48371-2.
[27] 周永红,周慧敏,康岩.糖尿病视网膜病变患者外周血微小RNA-181a与血管内皮生长因子水平及临床意义[J].广西医学,2019,41(22):2833-2836,2841.DOI:10.11675/j.issn.0253-4304.2019.22.04.
[28] Dong N,Tang X,Xu B.miRNA-181a inhibits the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells[J].Invest Ophthalmol Vis Sci,2015,56(2):993-1001.DOI:10.1167/iovs.14-15860.
[29] 田思佳,王骞,张蕾,等.miR-181a靶向沉默信息调节因子相关酶1在过氧化氢诱导的人小梁网细胞氧化应激中的调节作用[J].眼科新进展,2021,41(9):826-830.DOI:10.13389/j.cnki.rao.2021.0173.
[30] Ryan DG,Oliveira-Fernandes M,Lavker RM.MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity[J].Mol Vis,2006,12:1175-1184.
[31] Karali M,Peluso I,Marigo V,et al.Identification and characterization of microRNAs expressed in the mouse eye[J].Invest Ophthalmol Vis Sci,2007,48(2):509-515.DOI:10.1167/iovs.06-0866.
[32] Zhuang P,Zhang H,Welchko RM,et al.Combined microRNA and mRNA detection in mammalian retinas by in situ hybridization chain reaction[J].Sci Rep,2020,10(1):351.DOI:10.1038/s41598-019-57194-0.
[33] Carrella S,D'Agostino Y,Barbato S,et al.miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth[J].Dev Neurobiol,2015,75(11):1252-1267.DOI:10.1002/dneu.22282.
[34] Carrella S,Barbato S,D'Agostino Y,et al.TGF-beta controls miR-181/ERK regulatory network during retinal axon specification and growth[J].PLoS One,2015,10(12):e0144129.DOI:10.1371/journal.pone.0144129.
[35] He Y,Liu JN,Zhang JJ,et al.Involvement of microRNA-181a and bim in a rat model of retinal ischemia-reperfusion injury[J].Int J Ophthalmol,2016,9(1):33-40.DOI:10.18240/ijo.2016.01.06.
[36] Indrieri A,Carrella S,Romano A,et al.miR-181a/b downregulation exerts a protective action on mitochondrial disease models[J].EMBO Mol Med,2019,11(5):e8734.DOI:10.15252/emmm.201708734.
[37] Mead B,Kerr A,Nakaya N,et al.miRNA changes in retinal ganglion cells after optic nerve crush and glaucomatous damage[J].Cells,2021,10(7):1564.DOI:10.3390/cells10071564.
[38] Yang C,Tahiri H,Cai C,et al.microRNA-181a inhibits ocular neovascularization by interfering with vascular endothelial growth factor expression[J].Cardiovasc Ther,2018,36(3):e12329.DOI:10.1111/1755-5922.12329.
[39] Chen X,Li X,Liu Y,et al.MicroRNA expression analysis of mice retinas with oxygen-induced retinopathy by RNA sequencing[J].J Ophthalmol,2022,2022:9738068.DOI:10.1155/2022/9738068.
[40] Yang Y,Mei Q.miRNA signature identification of retinoblastoma and the correlations between differentially expressed miRNAs during retinoblastoma progression[J].Mol Vis,2015,21:1307-1317.
[41] Ouyang M,Liu G,Xiong C,et al.microRNA-181a-5p impedes the proliferation, migration, and invasion of retinoblastoma cells by targeting the NRAS proto-oncogene[J].Clinics (Sao Paulo),2022,77:100026.DOI:10.1016/j.clinsp.2022.100026.
[42] Tabatabaei SN,Derbali RM,Yang C,et al.Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma[J].J Control Release,2019,298:177-185.DOI:10.1016/j.jconrel.2019.02.014.
[43] Jiang Y,Gong Y,Lin N,et al.Expression of miR-181a and TGF-beta2 in lens epithelial cells of patients with cataractous retinal detachment and its clinical significance[J].Exp Ther Med,2019,17(6):4435-4440.DOI:10.3892/etm.2019.7488.
[44] Ling J,Tan K,Lu L,et al.lncRNA MIAT increases cell viability, migration, EMT and ECM production in age-related cataracts by regulating the miR-181a/CTGF/ERK signaling pathway[J].Exp Ther Med,2020,20(2):1053-1063.DOI:10.3892/etm.2020.8749.
[45] 秦宇,赵江月,罗文婷,等.miR-181调控人晶状体上皮细胞凋亡的机制研究[J].国际眼科杂志,2015,15(5):759-763.DOI:10.3980/j.issn.1672-5123.2015.5.04.
[46] 孔俐,文燕,刘真,等.年龄相关性白内障晶状体上皮细胞中miR-181a和SIRT1的表达关系及意义[J].中国老年学杂志,2020,40(6):1274-1278.DOI:10.3969/j.issn.1005-9202.2020.06.050.
[47] Chen X,Hu J.Long noncoding RNA 3632454L22Rik contributes to corneal epithelial wound healing by sponging miR-181a-5p in diabetic mice[J].Invest Ophthalmol Vis Sci,2021,62(14):16.DOI:10.1167/iovs.62.14.16.
[48] Jayaram H,Cepurna WO,Johnson EC,et al.MicroRNA expression in the glaucomatous retina[J].Invest Ophthalmol Vis Sci,2015,56(13):7971-7982.DOI:10.1167/iovs.15-18088.
[49] Zhang L,He X,Li F,et al.The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma[J].J Exp Clin Cancer Res,2018,37(1):15.DOI:10.1186/s13046-018-0679-5.