Research progress on pathogenesis and clinical treatment of non-alcoholic fatty liver disease

doi:10.3760/cma.j.cn441417-20250423-20012

Abstract

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease. Its pathogenesis is closely associated with insulin resistance, lipid metabolism imbalance, and cellular stress responses. It is a complex disease linked to systemic metabolic disorders. NAFLD has become the leading cause of chronic liver disease worldwide, without specific therapeutic measures. This article systematically reviews the core pathological mechanisms and clinical treatment advancements of NAFLD, so as to provide a theoretical basis for understanding the pathophysiological processes of NAFLD and the development of new diagnostic and therapeutic strategies.

Key words:

Non-alcoholic fatty liver disease, Pathogenesis, Clinical treatment, Progress

摘要：

非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）是一种慢性肝病，其发病机制与胰岛素抵抗、脂质代谢失衡及细胞应激反应等紧密关联，是一种与全身代谢紊乱相关的复杂疾病。NAFLD已成为全球慢性肝病的首要病因，临床仍缺乏特异性治疗手段。本文系统综述了NAFLD的核心病理机制与临床治疗进展，以期为深入理解NAFLD的病理生理过程、开发新的诊断和治疗策略提供理论依据。

关键词:

非酒精性脂肪肝病, 发病机制, 临床治疗, 进展

Liu Mengfan, Zhang Lingyun.

Research progress on pathogenesis and clinical treatment of non-alcoholic fatty liver disease [J]. International Medicine and Health Guidance News, 2025, 31(20): 3402-3406.

刘梦凡张凌云.

非酒精性脂肪肝病的发病机制与临床治疗研究进展 [J]. 国际医药卫生导报, 2025, 31(20): 3402-3406.

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