Detection of allergens in patients with allergic diseases at a
traditional Chinese hospital in Guangzhou

doi:10.3760/cma.j.issn.1007-1245.2022.07.009

Abstract

Abstract: Objective　To analyze the allergens in patients with allergic diseases. Methods　The allergen specific immunoglobulin E (IgE) antibodies in 507 patients treated at Department of Pediatrics, Department of Respiratory Medicine, and Department of Otolaryngology at Guangdong Second Hospital of Traditional Chinese Medicine from November 2019 to October 2020 were detected by the immunoblotting. The allergen distribution and statistical differences were analyzed by χ². Results　Among the 507 patients, there were 267 males and 240 females, and they were 2-90 years old. Four hundred and two patients were positive in the allergen detection, with a positive rate of 79.4% (212/267) in the male and a positive rate of 79.2% (190/240) in the female, and there was no statistical difference between the male and the female (χ²=0.82, P>0.05). There were statistical differences in the positive rate between the age groups (χ²=36.92, P<0.05) and between seasons (χ²=45.60, P<0.05). The positive rate of inhaled allergens was higher than that of ingested allergens; the main inhaled allergens were household dust mites [62.2% (250/402)] , dust mites [56% (225/402)], and cockroaches [50% (201/402)], and the main ingested allergens were egg white [22.9% (92/402) and milk [19.9% (80/402)]. Conclusions　The main allergens in patients at Guangdong Second Hospital of Traditional Chinese Medicine are household dust mites , dust mites, milk, egg white, and cockroaches. There are differences between age groups, and seasons.

Key words: Allergic diseases, Allergens, Specific IgE

摘要： 目的　探讨过敏性患者的过敏原情况。方法　共纳入2019年11月至2020年10月期间来广东省第二中医院儿科、呼吸科、耳鼻喉科等科室就诊的507例患者为研究对象，采用免疫印迹法进行过敏原特异性免疫球蛋白E（immunoglobulin E，IgE）抗体检测，用χ²检验分析过敏原分布情况及统计学差异。结果　在507患者标本中，男267例，女240例，年龄2～90岁。过敏原检测结果阳性者402例，其中男性阳性率为79.4%（212/267），女性阳性率79.2%（190/240），两者差异无统计学意义（χ²=0.82，P>0.05）。而过敏原阳性年龄分布差异有统计学意义（χ²=36.92，P<0.05），季节分布差异有统计学意义（χ²=45.60，P<0.05）。其中吸入性过敏原阳性率高于食入性过敏原，吸入性过敏原主要以户尘螨（62.2%，250/402）、粉尘螨（55.9%，225/402）及蟑螂（50.0%，201/402）为主，食入性过敏原以鸡蛋白（22.9%，92/402）和牛奶（19.9%，80/402）为主。结论　广东省第二中医院过敏性患者的过敏原以户尘螨、粉尘螨、牛奶、鸡蛋白和蟑螂为主，不同年龄和季节分布存在一定差异，日常生活可以重点关注。

关键词: 过敏性疾病, 过敏原, 特异性IgE

Deng Chao, Shen Sujing, Liang Ming, Zhu Zhuojun. Detection of allergens in patients with allergic diseases at a traditional Chinese hospital in Guangzhou[J]. International Medicine and Health Guidance News, 2022, 28(7): 924-928.

邓超, 沈素晶, 梁铭, 朱卓均. 广州市某中医院过敏性疾病过敏原检测分析[J]. 国际医药卫生导报, 2022, 28(7): 924-928.

References

[1] 王科惠,黄韵,张正银,等.IL-6、CRP和血清过敏原检测对急性荨麻疹的临床价值[J].检验医学,2021,36(3):300-303.DOI:10.3969/j.issn.1673-8640.2021.03.014.

[2] 傅玲琳,王彦波. 食物过敏:从致敏机理到控制策略[J]. 食品科学,2021,42(19):1-19. DOI:10.7506/spkx1002-6630- 20210726-302.

[3] 孙培静,刘海霞,张心梅.过敏性紫癜患者血清中过敏原特异性IgE和总IgE水平及临床意义[J].中国实验诊断学,2021,25(6):821-824.DOI:10.3969/j.issn.1007-4287. 2021.06.008.

[4] 王炎,田露芳,龚静蓉,等.上海闵行区变应性鼻炎患者血清过敏原分析[J].检验医学与临床,2021,18(13):1839-1842.DOI:10.3969/j.issn.1672-9455.2021.13.005.

[5] 陈纯,闵玮,于亚峰,等.苏州地区变应性鼻炎和特应性皮炎患者过敏原特异性IgE的对比分析[J].中国中西医结合耳鼻咽喉科杂志,2021,29(3):195-199.DOI:10.16542/j.cnki.issn.1007-4856.2021.03.009.

[6] 路瑞静,纪梓良,翟庆娜,等.深圳地区1266例儿童过敏原特异性sIgE检测结果分析[J].中国实验诊断学,2021,25(7):953-958.DOI:10.3969/j.issn.1007-4287.2021.07.002.

[7] 马婷婷,王洪田,陈艳蕾,等.北京地区门诊患者常见吸入过敏原致敏谱[J].中华临床免疫和变态反应杂志,2021,15(2):136-143.DOI:10.3969/j.issn.1673-8705.2021.02.002.

[8] 万极硕,卢山,杨凯楠.北京市昌平地区5068例过敏原特异性IgE抗体检测结果分析[J].标记免疫分析与临床,2021,28(3):385-390,394.DOI:10.11748/bjmy.issn.1006-1703. 2021. 03.006.

[9] 郑佩燕,简幸仪,黄惠敏,等.广州地区过敏疾病患者15种常见过敏原分布规律分析[J].贵阳医学院学报,2015,40(11):1197-1201. DOI:10.19367/j.cnki.1000-2707.2015.11.017.

[10] 王青波,林宏,吴海燕.848例儿童过敏性疾病血清样本过敏原检测分析[J].标记免疫分析与临床,2021,28(4):587-590.DOI:10.11748/bjmy.issn.1006-1703.2021.04.011.

[11] 卢晓荷,张恒,刘礼青,等.过敏性皮肤病患者血清过敏原特异性IgE抗体检测结果分析[J].检验医学与临床,2021,18(22):3312-3316.DOI:10.3969/j.issn.1672-9455. 2021. 22.027.

[12] de Jong AB, Dikkeschei LD, Brand PL. Sensitization patterns to food and inhalant allergens in childhood: a comparison of non-sensitized, monosensitized, and polysensitized children[J]. Pediatr Allergy Immunol, 2011,22(2):166-171. DOI: 10.1111/j.1399-3038.2010.00993.x.

[13] Craig TJ, King TS, Lemanske RF, et al. Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma[J]. J Allergy Clin Immunol, 2008,121(3):671-677. DOI: 10.1016/j.jaci.2007.12.1153.

[14] Sommanus S, Kerddonfak S, Kamchaisatian W, et al. Cow's milk protein allergy: immunological response in children with cow's milk protein tolerance[J]. Asian Pac J Allergy Immunol, 2014,32(2):171-177. DOI: 10.12932/AP0319. 32.2.2013.

[15] Oyoshi MK, Oettgen HC, Chatila TA, et al. Food allergy: Insights into etiology, prevention, and treatment provided by murine models[J]. J Allergy Clin Immunol, 2014,133(2):309-317. DOI: 10.1016/j.jaci.2013.12.1045.

[16] 陈广道,吴子谕,刘运可,等.广州地区哮喘及变应性鼻炎和湿疹儿童血清特异性过敏原IgE的对比分析[J].国际医药卫生导报,2020,26(14):2104-2107.DOI:10.3760/cma.j.issn.1007-1245.2020.14.031.

[17] 赖科峰,连炬飞,陈柳青,等.14048例儿童过敏原综合组(20)检测的流行病学分析[J].国际医药卫生导报,2019,25(9):1427-1432.DOI:10.3760/cma.j.issn.1007-1245.2019. 09.021.

[18] Nakajima-Adachi H, Shibahara K, Fujimura Y,et al. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy[J]. PLoS One, 2017,12(2):e0172795. DOI: 10.1371/journal.pone.0172795.

[19] Chen T, Liu X, Ma L, et al. Food allergens affect the intestinal tight junction permeability in inducing intestinal food allergy in rats[J]. Asian Pac J Allergy Immunol, 2014,32(4):345-353. DOI: 10.12932/AP0443. 32.4.2014.

[20] 郭玉蔓,罗晨,郅莉莉,等. 模拟消化方法在食物过敏原潜在致敏性评价中的应用进展[J]. 食品工业科技,2021,42(17):397-404. DOI:10.13386/j.issn1002-0306.2020080010.

[21] 赵凯,王玉杰,胡剑,等.苏州儿童呼吸系统疾病血清吸入性过敏原分析[J].中国妇幼健康研究,2017,28(12):1554-1556.DOI:10.3969/j.issn.1673-5293.2017.12.017.

[22] 杜静,朱天川,周薇,等.过敏性皮肤病患者血清特异性过敏原IgE分析[J].国际检验医学杂志,2016,37(11):1537-1539.DOI:10.3969/j.issn.1673-4130.2016.11.036.

[23] 汪宝贯.临床患者过敏原感染谱特征及应用价值探讨[J].检验医学与临床,2021,18(14):2107-2110.DOI:10.3969/j.issn.1672-9455.2021.14.034.

[24] 孙一帆,黄建芳,王彩霞,等.中国人的虾、蟹致敏过敏原组分分析[J].中国免疫学杂志,2014,30(10):1325-1329.DOI:10.3969/j.issn.1000-484X.2014.10.006.

[25] 杨捷,曾仁山,方锐华,等.2333例变应性皮肤病患者血清过敏原检测分析[J].国际医药卫生导报,2006,12(6):84-85.DOI:10.3760/cma.j.issn.1007-1245.2006.06.045.

[26] 陈黎,韩碧芸,张泓,等.57185例过敏性疾病患儿过敏原特异性IgE检测结果分析[J].检验医学,2021,36(9):920-924.DOI:10.3969/j.issn.1673-8640.2021.09.007.

[27] 吴倩,陈萍,王博鹤.1194例特应性皮炎患儿血清过敏原检测及分析[J].徐州医科大学学报,2021,41(1):62-66.DOI:10.3969/j.issn.2096-3882.2021.01.013.

[28] 闫津津,冯珍如,王美玲,等.北京地区人群血清抗交叉反应性糖类决定簇IgE检测与分布特征分析[J].中国全科医学,2013,16(21):2520-2522.DOI:10.3969/j.issn.1007-9572. 2013.21.029.

Detection of allergens in patients with allergic diseases at a traditional Chinese hospital in Guangzhou

广州市某中医院过敏性疾病过敏原检测分析

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 0

Recommended Articles

Metrics