Abstract:

Objective　To observe the effect of Chinese medicine granule soaking and washing combined with naftifine/ketoconazole cream in the treatment of interlacing erosion tinea of hands and feet. Methods　From April 2023 to April 2024, 120 patients with interlacing erosion tinea of hands and feet admitted to Guangzhou Dermatology Hospital of Zhongshan Fourth Road were selected for a prospective study, and were divided into a control group and an observation group by the random number table method, with 60 cases in each group. In the control group, there were 35 males and 25 females, aged (37.65±10.66) years, and the course of disease was (16.75±9.16) months. In the observation group, there were 32 males and 28 females, aged (38.25±10.17) years, and the course of disease was (15.23±8.41) months. The control group was treated with external application of naftifine/ketoconazole cream, and the dosage was one fingertip unit, twice a day. On the basis of the treatment of the control group, the observation group was treated with Chinese medicine granule soaking and washing, and the granule formula was: kuhseng, shechuangzi, cortexphellodendri, and garden burnet root granules, once a day, 20 min each time. Both groups were treated for 4 weeks. The scores of skin related symptoms before and after treatment, therapeutic effect, and safety were compared between the two groups. Statistical methods used were χ² test and t test. Results　After treatment, the scores of skin damage, pruritus, effusion, and pain in the observation group were lower than those in the control group [(0.45±0.15) points vs. (1.34±0.17) points, (0.66±0.14) points vs. (1.42±0.21) points, (0.53±0.14) points vs. (1.38±0.18) points, (0.55±0.12) points vs. (1.33±0.19) points], with statistically significant differences (t=10.78, 10.53, 10.56, and 10.11, all P<0.05). The total effective rate of the observation group was higher than that of the control group [88.33% (53/60) vs. 65.00% (39/60)], with a statistically significant difference (χ²=9.37, P<0.05). The fungal clearance rate of the observation group was higher than that of the control group [86.67% (52/60) vs. 68.33% (41/60)], with a statistically significant difference (χ²=8.67, P<0.05). During treatment, no significant adverse symptoms were observed in both groups. Conclusion　On the basis of naftifine/ketoconazole cream, combined application of Chinese medicine granule soaking formula can effectively improve the treatment effect of interlacing erosion tinea of hands and feet, and it is safe and worthy of clinical promotion.

Key words:

Chinese medicine granule soaking formula, Naftifine/ketoconazole cream, Interlacing erosion tinea of hands and feet, Clinical effect

摘要：

目的　观察中药颗粒浸泡方联合萘替芬酮康唑乳膏治疗间擦糜烂型手足癣患者的临床效果。方法　选取2023年4月至2024年4月广州市皮肤病医院门诊部收治的120例间擦糜烂型手足癣患者进行前瞻性研究，采取随机数字表法分为对照组和观察组，各60例。对照组男35例、女25例，年龄（37.65±10.66）岁，病程（16.75±9.16）个月；采用萘替芬酮康唑乳膏外涂治疗，用药量参照一指尖单位使用，2次/d。观察组男32例、女28例，年龄（38.25±10.17）岁，病程（15.23±8.41）个月；在对照组的治疗基础上联合协定中药颗粒浸泡方泡洗治疗，颗粒剂配方：苦参、蛇床子、黄柏、地榆颗粒，１次/d，每次20 min。两组均治疗4周。比较两组治疗前、后皮肤相关症状评分、治疗效果及治疗安全性。统计学方法采用χ²检验和t检验。结果　治疗后，观察组患者皮肤破损、瘙痒、渗液、疼痛症状积分均低于对照组［（0.45±0.15）分比（1.34±0.17）分、（0.66±0.14）分比（1.42±0.21）分、（0.53±0.14）分比（1.38±0.18）分、（0.55±0.12）分比（1.33±0.19）分］，差异均有统计学意义（t=10.78、10.53、10.56、10.11，均P<0.05）。观察组治疗总有效率高于对照组［88.33%（53/60）比65.00%（39/60）］，差异有统计学意义（χ²=9.37，P<0.05）。观察组真菌清除率高于对照组［86.67%（52/60）比68.33%（41/60）］，差异有统计学意义（χ²=8.67，P<0.05）。治疗期间，两组患者均未见明显的不良反应。结论　在萘替芬酮康唑乳膏的基础上辅以中药颗粒浸泡方治疗间擦糜烂型手足癣患者，可提高治疗效果，且安全性好，值得临床推广。

关键词:

中药颗粒浸泡方, 萘替芬酮康唑乳膏, 间擦糜烂型手足癣, 临床效果