Abstract: Objective　To analyze the therapeutic effect of methylprednisolone combined with lidocaine in refractory sudden deafness with tinnitus, and its influence on the mean value of pure tone hearing threshold and adverse reactions. Methods　In the retrospective analysis, 160 patients with refractory sudden deafness with tinnitus admitted to Maternity and Child Health Hospital of Jiaozuo City from January 2020 to September 2021 were selected as the research objects. According to the random number table method, they were divided into a control group (80 cases) and an observation group (80 cases). In the control group, there were 45 males and 35 females, with an age of (50.52±3.82) years old; there were 41 males and 39 females in the observation group, with an age of (50.98±3.99) years old. Both groups received conventional treatment, and the observation group was given methylprednisolone and lidocaine for combined treatment. The improvement of ear function, adverse reactions, and medication effects of the two groups were compared. Independent sample t test was used for inter-group comparison of the measurement data, paired t test was used for intra-group comparison of the measurement data, and χ² test was used for the count data. Results　Before treatment, there were no statistically significant differences in the mean pure tone threshold and Tinnitus Handicap Inventory (THI) score between the two groups (both P>0.05); after treatment, the mean pure tone threshold and THI score of the observation group were (40.03±3.55) dB and (13.85±2.01) points, respectively, which were lower than those of the control group [(51.95±4.14) dB and (19.95±2.75) points], with statistically significant differences (both P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ²=0.826, P=0.363). The total effective rate of the observation group was 98.75% (79/80), which was higher than that of the control group [90.00% (72/80)], with a statistically significant difference (χ²=4.238, P=0.040). Conclusion　The combined use of methylprednisolone and lidocaine in the clinical treatment of patients with refractory sudden deafness with tinnitus can promote the improvement and recovery of symptoms such as hearing loss and tinnitus, and can reduce the occurrence risk of adverse reactions in patients and improve the efficacy of patients' medication, which is worthy of promotion and application.

Key words:

"> Refractory sudden deafness, Tinnitus, Methylprednisolone, Lidocaine, Therapeutic effect, Mean pure tone threshold

摘要： 目的　探析甲泼尼龙和利多卡因在难治性突发性聋伴耳鸣中的治疗效果，及对纯音听阈均值、不良反应的影响。方法　回顾性分析，选择2020年1月至2021年9月焦作市妇幼保健院收治的难治性突发性聋伴耳鸣患者160例作为研究对象，按随机数字表法分为对照组和观察组，各80例。对照组男45例、女35例，年龄（50.52±3.82）岁，采用常规治疗；观察组男41例、女39例，年龄（50.98±3.99）岁，在常规治疗基础上行甲泼尼龙和利多卡因进行联合治疗。对比两组耳功能改善情况、不良反应及用药效果。计量资料组间比较采用独立样本t检验，组内采用配对t检验，计数资料采用χ²检验。结果　治疗前，两组难治性突发性聋伴耳鸣患者纯音听阈均值、耳鸣致残量表（THI）评分比较，差异均无统计学意义（均P>0.05）；治疗后，观察组纯音听阈均值、THL评分分别为（40.03±3.55）dB、（13.85±2.01）分，均低于对照组的（51.95±4.14）dB、（19.95±2.75）分，差异均有统计学意义（均P<0.05）。两组难治性突发性聋伴耳鸣患者不良反应发生率比较，差异无统计学意义（χ²=0.826，P=0.363）。观察组治疗后总有效率为98.75%（79/80），高于对照组90.00%（72/80），差异有统计学意义（χ²=4.238，P=0.040）。结论　将甲泼尼龙与利多卡因联合用药方式在难治性突发性聋伴耳鸣患者的临床治疗中，能促进听力下降、耳鸣等症状的改善与恢复，对降低患者的不良反应发生风险、提升患者的用药疗效均有重要作用，值得推广应用。

关键词: 难治性突发性聋, 耳鸣, 甲泼尼龙, 利多卡因, 治疗效果, 纯音听阈均值