Research progress of Wnt signaling pathway in acute myocardial infarction

doi:10.3760/cma.j.issn.1007-1245.2024.08.013

Abstract

Abstract:

Wnt signaling pathway is a signal transduction pathway by which ligand protein Wnt binds to membrane protein receptors to stimulate downstream signaling molecules to produce cascade reactions. Wnt signaling pathway is a key pathway to regulate cell growth, proliferation, and differentiation. After acute myocardial infarction (AMI), the regeneration capacity of cardiomyocytes is limited, the fibroblasts multiply greatly, and the scar tissue is formed. Myocardial remodeling leads to decreased left ventricular function. Therefore, promoting myocardial regeneration and reducing scar area are of great significance for improving cardiac function after myocardial infarction. Wnt signaling pathway is involved both in normal cardiomyocytes and in the formation and development of cardiovascular diseases. The study on the role of Wnt signaling pathway in AMI can provide a new basis for the treatment of AMI. In this paper, we review the research progress of Wnt signaling pathway in the development of AMI.

Key words:

Acute myocardial infarction, Wnt signaling pathway, Cardiomyocytes, Stem cell transplantation, Progress

摘要：

Wnt信号通路是由配体蛋白Wnt和膜蛋白受体结合激发下游信号分子产生级联反应的信号转导途径。Wnt信号通路是调控细胞生长、增殖、分化的关键途径。急性心肌梗死（AMI）后心肌细胞再生能力有限，成纤维细胞大量增殖，形成瘢痕组织，心肌重构导致左心室功能下降。因此，促进心肌再生、减少瘢痕面积对于心肌梗死后心脏功能的改善具有重要意义。无论是在正常的心肌细胞还是心血管疾病形成和发展过程中，均有Wnt信号通路的参与。研究Wnt信号通路在AMI中的作用可以为AMI治疗提供新的依据与思路。本文对Wnt信号通路在AMI发展过程中的相关研究进展进行综述。

关键词:

急性心肌梗死, Wnt信号通路, 心肌细胞, 干细胞移植, 进展

Yang Shoujuan, Zhang Haitao, Cui Mingli, Wang Jian, Li Yang, Cheng Yanli.

Research progress of Wnt signaling pathway in acute myocardial infarction [J]. International Medicine and Health Guidance News, 2024, 30(8): 1291-1296.

杨寿娟张海涛崔明丽王建李洋程艳丽.

Wnt信号通路在急性心肌梗死中的研究进展 [J]. 国际医药卫生导报, 2024, 30(8): 1291-1296.

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