Role of capsaicin receptors in pathogenesis of diarrheal irritable bowel syndrome

doi:10.3760/cma.j.issn.1007-1245.2024.07.003

Abstract

Abstract:

Diarrheal irritable bowel syndrome (IBS-D) is one of the common functional gastrointestinal disorders characterized by intermittent abdominal pain and diarrhea. IBS-D is a chronic functional disease with a long course and easy recurrence of symptoms, and seriously affects the patients' quality of life. At present, it is believed that its pathogenesis is closely related to factors such as visceral hypersensitivity, brain-gut axis imbalance, intestinal flora imbalance, etc. Current studies have shown that capsaicin receptors are involved and play an important role. In this article, the specific mechanism of capsaicin receptors involved in visceral hypersensitivity, brain-gut axis imbalance, and intestinal flora imbalance is reviewed, so as to provide references for exploring the pathogenesis and therapeutic targets of IBS-D.

Key words:

Diarrheal irritable bowel syndrome, Capsaicin receptors, Visceral hypersensitivity, Brain-gut axis, Intestinal flora, Review

摘要：

腹泻型肠易激综合征（diarrheal irritable bowel syndrome，IBS-D）是常见的功能性胃肠疾病之一，其典型症状为间断性腹痛、腹泻。IBS-D有病程长、症状易反复等特点，是一种严重影响患者生活质量的慢性功能性疾病。目前，研究认为，其发病机制与内脏高敏感、脑-肠轴失衡、肠道菌群失调等因素相关。有研究表明，辣椒素受体参与其中并发挥了重要作用。本文就辣椒素受体参与内脏高敏感、脑-肠轴失衡、肠道菌群失调发生的具体机制作一综述，以期为探索IBS-D发病机制及治疗靶点提供参考。

关键词:

腹泻型肠易激综合征, 辣椒素受体, 内脏高敏感, 脑-肠轴, 肠道菌群, 综述

Cui Xiao, Liu Liang.

Role of capsaicin receptors in pathogenesis of diarrheal irritable bowel syndrome [J]. International Medicine and Health Guidance News, 2024, 30(7): 1066-1070.

崔筱刘亮.

辣椒素受体在腹泻型肠易激综合征发病中的作用 [J]. 国际医药卫生导报, 2024, 30(7): 1066-1070.

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