Research progress of PD-L1 and tumor-associated macrophages in breast cancer

doi:10.3760/cma.j.issn.1007-1245.2024.05.005

Abstract

Abstract:

Tumor microenvironment has many components that play an immunosuppressive role; among which, programmed cell death-ligand 1 (PD-L1) is closely related to tumor-associated macrophages (TAMs), and plays a vital role in the occurrence and development of breast cancer. This article reviews the significance of PD-L1 and TAMs in the occurrence and development of breast cancer and the possible interaction mechanism between them, as well as the effects of anti-programmed cell death protein-1 (PD-1)/PD-L1 combined with targeting TAMs in the treatment of breast cancer.

Key words:

Breast neoplasm, PD-L1, Tumor-associated macrophages, Immunosuppression, Tumor microenvironment, Progress

摘要：

肿瘤微环境中存在着许多发挥免疫抑制作用的成分，其中程序性细胞死亡配体-1（PD-L1）与肿瘤相关巨噬细胞（TAMs）关系密切，其在乳腺癌的发生发展中发挥重要作用。本文对PD-L1和TAMs在乳腺癌发生发展中的意义和两者之间可能存在的相互作用机制，以及靶向TAMs在抗程序性细胞死亡受体-1（PD-1）/PD-L1治疗乳腺癌中的影响进行综述。

关键词:

乳腺癌, PD-L1, 肿瘤相关巨噬细胞, 免疫抑制, 肿瘤微环境, 进展

Chen Miaoling, Han Yuzhen.

Research progress of PD-L1 and tumor-associated macrophages in breast cancer [J]. International Medicine and Health Guidance News, 2024, 30(5): 732-735.

陈妙玲韩玉贞.

PD-L1与肿瘤相关巨噬细胞在乳腺癌中的研究进展 [J]. 国际医药卫生导报, 2024, 30(5): 732-735.

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