Sequential therapy combined with probiotics for helicobacter pylori: a meta-analysis

doi:10.3760/cma.j.issn.1007-1245.2023.24.014

International Medicine and Health Guidance News ›› 2023, Vol. 29 ›› Issue (24): 3590-3598.DOI: 10.3760/cma.j.issn.1007-1245.2023.24.014

• Meta Analysis • Previous Articles Next Articles

Sequential therapy combined with probiotics for helicobacter pylori: a meta-analysis

Xie Jiaxin¹, Diao Dechang², Wei Lin³, Liu Yangchen³, Tan Ping², You Jiuhong², Long Lifang⁴, Xie Xiangqi¹, Zhu Xinxin⁴, Lin Meizhen³

¹Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China; ²Gastrointestinal Tumor Center, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China; ³Department of Nursing, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China; ⁴College of Nursing, Hunan University of Traditional Chinese Medicine, Changsha 410208, China

Received:2023-08-14 Online:2023-12-15 Published:2024-01-04
Contact: Lin Meizhen, Email: lmzmay@163.com
Supported by:
Project of Plan of Science and Technology in Guangzhou (202102010240 and 202002030436); Special Project of Science and Technology of Chinese Medicine at Guangdong Provincial Hospital of Traditional Chinese Medicine (YN2022HL.01)

序贯疗法联合益生菌对幽门螺杆菌疗效的meta分析

谢嘉欣¹ 刁德昌² 魏琳³ 刘杨晨³ 谭萍² 尤久红² 隆丽芳⁴ 谢湘萁¹ 朱鑫鑫⁴ 林美珍³

¹广州中医药大学第二临床医学院，广州　510405；²广东省中医院胃肠肿瘤中心，广州　510120；³广东省中医院护理部，广州　510120；⁴湖南中医药大学护理学院，长沙　410208

通讯作者: 林美珍，Email：lmzmay@163.com
基金资助:
广州市科技计划项目（202002030436、202102010240）；广东省中医院中医药科学技术研究专项（YN2022HL.01）

Abstract

Abstract:

Objective　To systematically evaluate the efficacy and safety of sequential therapy combined with probiotics in the treatment of Helicobacter pylori (Hp) infection. Methods　The randomized controlled trials of sequential therapy combined with probiotics in the treatment of Hp infection were retrieved from the establishment to June 20, 2022. The literatures were screened according to the inclusion criteria. The modified Jadad scale was used to evaluate the bias risk. The RevMan5.3 software was used for the statistics and analysis. Results　A total of 22 randomized controlled trials involving 3 158 patients were included. Meta-analysis results showed that the total negative conversion rate (OR=3.99, 95%CI 3.10-5.14, P < 0.001), effective rate (OR=4.98, 95%CI 3.57-6.94, P<0.001), recurrence rate (OR=0.20, 95%CI 0.07-0.56, P=0.002), symptom score (OR=-1.41, 95%CI -1.51--1.31, P<0.001 ), and incidence of adverse reactions (OR=0.28, 95%CI 0.21-0.36, P<0.001) of sequential therapy combined with probiotics in the treatment of Hp infection were better than those of the control group. Conclusion　The negative conversion rate and effective rate of sequential therapy combined with probiotics in the treatment of Hp infection are higher than those of the simple sequential therapy, and the symptom score, recurrence rate, and incidence of adverse reactions are lower.

Key words:

Sequential therapy, Probiotics, Helicobacter pylori infection, Adverse reactions, Meta-analysis

摘要：

目的　系统评价序贯疗法联合益生菌治疗幽门螺杆菌（Helicobacter pylori，Hp）感染的疗效和安全性。方法　检索从建库至2022年6月20日采用序贯疗法联合益生菌治疗Hp感染的随机对照试验研究，根据纳排标准筛选文献，用改良版Jadad量表进行偏倚风险的评价，采用RevMan 5.3软件进行统计与分析。结果　共纳入22项随机对照试验研究，总计3 158例患者。Meta分析结果显示：序贯疗法联合益生菌治疗Hp感染总转阴率（OR=3.99，95%CI 3.10～5.14，P<0.001）、有效率（OR=4.98，95%CI 3.57～6.94，P<0.001）、复发率（OR=0.20，95%CI 0.07～0.56，P=0.002）、症状积分（OR=-1.41，95%CI -1.51～-1.31，P<0.001）、不良反应率（OR=0.28，95%CI 0.21～0.36，P<0.001）均优于单纯序贯疗法。结论　与单纯序贯疗法治疗Hp感染相比，序贯疗法联合益生菌治疗Hp感染的转阴率和有效率更高，症状积分、复发率、不良反应发生率更低。

关键词:

序贯疗法, 益生菌, 幽门螺杆菌感染, 不良反应, meta分析

Xie Jiaxin, Diao Dechang, Wei Lin, Liu Yangchen, Tan Ping, You Jiuhong, Long Lifang, Xie Xiangqi, Zhu Xinxin, Lin Meizhen.

Sequential therapy combined with probiotics for helicobacter pylori: a meta-analysis [J]. International Medicine and Health Guidance News, 2023, 29(24): 3590-3598.

谢嘉欣刁德昌魏琳刘杨晨谭萍尤久红隆丽芳谢湘萁朱鑫鑫林美珍.

序贯疗法联合益生菌对幽门螺杆菌疗效的meta分析 [J]. 国际医药卫生导报, 2023, 29(24): 3590-3598.

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Sequential therapy combined with probiotics for helicobacter pylori: a meta-analysis

序贯疗法联合益生菌对幽门螺杆菌疗效的meta分析

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