Application of dexmedetomidine and low-dose sufentanil in elderly patients taking painless gastroenterology and its effect on cognitive function

doi:10.3760/cma.j.issn.1007-1245.2023.10.014

Abstract

Abstract:

Objective　To explore the effect applying dexmedetomidine and low-dose sufentanil in elderly patients taking painless gastroenterology and its effect on cognitive function. Methods　A total of one hundred and ten elderly patients who underwent painless gastrointestinal endoscopy in Bayannur Hospital between March 2020 and May 2022 were selected for the randomized controlled trial, and were divided into a control group and a combination group by the random number table method, with 55 cases in each group. In the control group, there were 31 males and 24 females; they were 60-89 years old. In the combination group, there were 28 males and 27 females; they were 60-89 years old. The control group took small-dose sufentanil (0.1 μg/kg), and the combination group dexmedetomidine (0.5 μg/kg) and low-dose sufentanil (0.1 μg/kg). The anesthesia effects, cognitive function, and incidences of clinical adverse reactions were compared between the two groups. t and χ² tests were applied. Results　The anesthesia onset time, examination time, and time to wake up in the combination group were lower than those in the control group [(1.57±0.39) min vs. (1.87±0.46) min, (21.58±4.32) min vs. (24.57±4.91) min, and (21.47±4.29) min vs. (27.31±5.46) min], with statistical differences (t=3.689, 3.391, and 6.237; all P<0.05). There were no statistical differences in the scores of Lovingston Homework Therapy Cognitive Assessment (LOTCA) before the examination and 60 min after waking up between the two groups. The scores of LOTCA 15 and 30 min after waking up in the combination group were higher than those in the control group [(65.43±4.36) vs. (63.27±4.22) and (71.23±4.75) vs. (69.12±4.61)], with statistical differences (t=2.640 and 2.364; both P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion　Dexmedetomidine combined with low-dose sufentanil for elderly patients undergoing painless gastroenteroscopy has a better anesthetic effect, has less effect on patients' cognitive function, and is safe to use.

Key words:

Elderly patients, Painless gastroenteroscopy, Dexmedetomidine, Sufentanil, Low-dose, Cognitive function

摘要：

目的　探究右美托咪定复合小剂量舒芬太尼在老年无痛胃肠镜中的应用效果及对认知功能的影响。方法　选取2020年3月至2022年5月在巴彦淖尔市医院进行无痛胃肠镜检查的老年患者110例进行随机对照试验，随机数字表法将其均分为两组，每组55例。对照组男31例、女24例，年龄60～89岁，予以小剂量舒芬太尼（0.1 μg/kg）；联合组男28例、女27例，年龄60～89岁，予以右美托咪定（0.5 μg/kg）复合小剂量舒芬太尼（0.1 μg/kg）。比较两组麻醉效果、认知功能及临床不良反应发生情况。采用t、χ²检验进行统计比较。结果　联合组麻醉起效时间（1.57±0.39）min、检查时间（21.58±4.32）min、苏醒时间（21.47±4.29）min，均短于对照组［（1.87±0.46）min、（24.57±4.91）min、（27.31±5.46）min］，两组比较，差异均有统计学意义（t=3.689、3.391、6.237，均P<0.05）。两组患者检查前、苏醒后60 min洛文斯顿作业疗法认知评定量表（LOTCA）评分比较，差异均无统计学意义（均P>0.05）；联合组苏醒后15 min时LOTCA评分（65.43±4.36）分、苏醒后30 min时LOTCA评分（71.23±4.75）分，均高于对照组［（63.27±4.22）分、（69.12±4.61）分］，两组比较，差异均有统计学意义（t=2.640、2.364，均P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论　右美托咪定复合小剂量舒芬太尼用于老年无痛胃肠镜检查中，有较好麻醉效果，且对患者认知功能影响较小，用药较为安全。

关键词:

老年人, 无痛胃肠镜, 右美托咪定, 舒芬太尼, 小剂量, 认知功能

Wen Hairu, Zhang Le, Zhang Qin.

Application of dexmedetomidine and low-dose sufentanil in elderly patients taking painless gastroenterology and its effect on cognitive function [J]. International Medicine and Health Guidance News, 2023, 29(10): 1396-1399.

温海茹张乐张琴.

右美托咪定复合小剂量舒芬太尼在老年无痛胃肠镜中的效果及对认知功能影响 [J]. 国际医药卫生导报, 2023, 29(10): 1396-1399.

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