Abstract:

Objective　To investigate the clinical distribution and drug resistance of pathogenic bacteria in wound secretions of diabetic foot patients in Guangdong Second Traditional Chinese Medicine Hospital, and to provide bases for clinical medication planning. Methods　A retrospective analysis was performed in this study. The bacterial culture and drug sensitivity results of wound secretions of the hospitalized patients with diabetic foot diagnosed in Guangdong Second Traditional Chinese Medicine Hospital from January 2020 to December 2021 were derived through the laboratory information system; the distribution and drug resistance of pathogenic bacteria were analyzed. Excel was used for data processing and presentation. Results　A total of 102 patients with diabetic foot were hospitalized in Guangdong Second Traditional Chinese Medicine Hospital from January 2020 to December 2021; among which, 60 patients were complicated with pathogen infection, and the infection rate was 58.82%. There were 41 males (68.33%) and 19 females (31.67%); they were 33-87 years old. A total of 65 pathogenic bacteria were detected, including 21 strains of Gram-positive bacteria (32.31%) and 44 strains of Gram-negative bacteria (67.69%). The top three were Staphylococcus aureus (15.38%, 10/65), Escherichia coli (13.85%, 9/65), and Pseudomonas aeruginosa (10.77%, 7/65). Conclusions　Gram-negative bacteria are the main bacteria isolated from patients with diabetic foot infection in Guangdong Second Traditional Chinese Medicine Hospital; Staphylococcus aureus accounts for the highest proportion of pathogenic microorganism distribution. Antibiotics can be used according to the distribution of bacteria empirically; medication strategies should be adjusted timely according to drug sensitivity results to reduce the generation of multidrug-resistant bacteria.

Key words:

Diabetic foot infection, Distribution of pathogenic bacteria, Drug resistance

摘要：

目的　了解广东省第二中医院糖尿病足患者伤口分泌物中病原菌临床分布及其耐药性，为临床制定用药方案提供依据。方法　本研究采用回顾性分析。通过实验室信息系统导出2020年1月至2021年12月广东省第二中医院住院治疗且诊断为糖尿病足的患者伤口分泌物细菌培养及药敏结果，分析病原菌分布和耐药情况，并用Excel进行数据处理与呈现。结果　2020年1月至2021年12月广东省第二中医院收治糖尿病足患者102例，其中合并病原菌感染者60例，感染率为58.82%。合并感染患者中，男性41例（68.33%），女性19例（31.67%），年龄33～87岁。共分离临床菌株65株，其中革兰阳性菌21株（32.31%），革兰阴性菌44株（67.69%）。占比居前3位的菌株分别为金黄色葡萄球菌（15.38%，10/65）、大肠埃希菌（13.85%，9/65）、铜绿假单胞菌（10.77%，7/65）。结论　广东省第二中医院糖尿病足感染患者临床分离细菌以革兰阴性菌为主；病原微生物分布方面以金黄色葡萄球菌占比最高；经验用药可以根据细菌分布情况使用抗菌药物，并根据药敏结果及时调整用药策略，减少多重耐药菌的产生。

关键词:

糖尿病足感染, 病原菌分布, 耐药