Research progress on microRNA function and clinical value in colorectal cancer

doi:10.3760/cma.j.cn441417-20240918-06002

Abstract

Abstract:

Colorectal cancer (CRC) is one of the common gastrointestinal malignancies. The microRNA (miRNA) is a small single-stranded RNA with no coding function, can inhibit the expression of targeted genes, and regulates the physiological and pathological processes. Specific miRNAs can regulate the proliferation and invasion of CRC; as non-invasive biological markers, they have some value in the early diagnosis and prognosis assessment of CRC. CRC treatment methods targeting specific miRNAs have shown important value at basic research level, and also provide some references for the development of new CRC drugs.

Key words:

Colorectal cancer, MicroRNA, Diagnosis, Prognosis, Treatment, Progress

摘要：

结直肠癌（colorectal cancer，CRC）是常见的消化道恶性肿瘤之一。微小RNA（microRNA，miRNA）是一类无编码功能的单链小RNA，能够抑制靶向基因表达，从而发挥调控生理及病理过程的作用。特异性miRNA可以调控CRC的增殖及侵袭过程。特异性miRNA作为无创生物学标志物，在CRC的早期诊断及预后评估方面也有一定价值。靶向特异性miRNA的CRC治疗方法在基础研究层面显示出了一定价值，也为开发全新的CRC药物提供了参考。

关键词:

结直肠癌, 微小RNA, 诊断, 预后, 治疗, 进展

Zhu Peng, Tang Wenling, Qin Gang.

Research progress on microRNA function and clinical value in colorectal cancer [J]. International Medicine and Health Guidance News, 2025, 31(6): 886-890.

朱鹏唐文玲覃刚.

结直肠癌中微小RNA功能及临床价值进展 [J]. 国际医药卫生导报, 2025, 31(6): 886-890.

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