Abstract:

Objective　To explore the efficacy of Astragalus Tincture combined with massage on lipohypertrophy (LH) and blood glucose in patients with type 1 diabetes (T1DM). Methods　A prospective study was conducted to select T1 DM patients aged 3-16 years with LH at the insulin injection site who were followed up in the endocrinology clinic of Quanzhou Maternal and Child Health Hospital from May 2023 to March 2024. The patients were divided into control group and experimental group by random number method, with 30 cases in each group. A total of 5 cases were lost during the intervention, including 3 cases in the experimental group and 2 cases in the control group. All of them failed to be followed up in time after the intervention, and the improvement of LH could not be judged. In the control group, there were 15 males and 13 females, aged (10.50±2.59) years, and the course of disease was (34.14±19.42) months. There were 13 males and 14 females in the experimental group, aged (9.74±3.65) years old, and the course of disease was (32.67±18.98) months. The control group was treated with 25% magnesium sulfate hot and humid compress, and the experimental group was treated with Huangqi tincture rubbing + massage, 2 times/d, for 14 days.The improvement of LH, blood glucose compliance rate at different time periods [before three meals, 2 h after meals, before bedtime (22:00), early morning (03:00)] and the incidence of hypoglycemia were compared between the two groups after intervention. The statistical methods were t test, χ² test and rank sum test. Results　After the intervention, 23 cases (85.19%) in the experimental group and 16 cases (57.14%) in the control group showed effective improvement in LH, with statistical differences (χ²=5.240, P=0.022). There were statistically significant differences in blood glucose daily compliance between the two groups at different time periods after intervention (all P<0.05). There were 11 cases of hypoglycemia in the two groups, including 2 cases (7.41% ) in the experimental group and 9 cases (32.14%) in the control group, with statistical differences (χ²=4.313, P=0.038). Conclusions　Astragalus tincture combined with massage can effectively improve LH levels in patients with T1DM, which is beneficial for controlling their blood sugar and reducing the occurrence of hypoglycemic events.

Key words:

Type 1 diabetes, Lipohypertrophy, Astragalus tincture, Blood glucose, Massage

摘要：

目的　探讨黄芪酊+按摩对1型糖尿病（T1DM）患者皮下脂肪增生（LH）疗效及血糖的影响。方法　前瞻性研究，选取2023年5月至2024年3月泉州市妇幼保健院内分泌科门诊随访诊治的3～16岁伴有胰岛素注射部位LH的T1DM患者，采用随机数字法分为对照组和试验组，各30例。干预期间共脱落5例，其中试验组3例，对照组2例，均在干预结束后未能及时门诊随访，无法判断LH改善情况。对照组男15例、女13例，年龄（10.50±2.59）岁，病程（34.14±19.42）个月；试验组男13例、女14例，年龄（9.74±3.65）岁，病程（32.67±18.98）个月。对照组采用25%硫酸镁湿热敷，试验组采用黄芪酊涂擦+按摩，2次/d，干预14 d。对比干预后两组患者LH改善情况、不同时间段血糖达标率［三餐前、餐后2 h、睡前（22∶00）、凌晨（03∶00）］和低血糖发生率。统计学方法采用t检验、χ²检验、秩和检验。结果　干预后，试验组LH改善有效23例（85.19%），对照组改善有效16例（57.14%），差异有统计学意义（χ²=5.240，P=0.022）。两组患者干预后不同时间段血糖日达标情况比较，差异均有统计学意义（均P<0.05）。两组患者共有11例发生低血糖事件，其中试验组2例（7.41%），对照组9例（32.14%），差异有统计学意义（χ²=4.313，P=0.038）。结论　黄芪酊+按摩可有效改善T1DM患者LH，控制血糖，减少低血糖事件发生。

关键词:

1型糖尿病, 脂肪增生, 黄芪酊, 血糖, 按摩