Abstract:

Objective　To explore the correlation between the symptom group scores of the Multidimensional Fatigue Scale (MFI-20) in children with glioma and their quality of life. Methods　A total of 90 children with glioma admitted to Xi'an Children's Hospital were selected by  the continuous sampling method. The research period was from March 2019 to February 2024. Among them, there were 42 males and 48 females, with ages ranging from 1 to 16 (5.34±1.12) years old. The fatigue symptoms and quality of life of the children were evaluated through the MFI-20 and the European Organization for Research and Treatment of Cancer's Quality of Life Core Questionnaire (EORTC QLQ-C30), and the correlation between the two was analyzed. Statistical methods employed included t-test, univariate analysis, Pearson linear regression analysis, and multivariate logistic regression analysis. Results　Among the 90 children, 72 showed symptoms of fatigue, with an incidence rate of 80.00%. The total score was (60.46±5.51) points, and the overall quality of life score was (67.23±3.89) points.The single-factor analysis showed that there were statistically significant differences in the total quality of life scores among children of different ages, tumor grades, the number of radiotherapy and chemotherapy sessions, and KPS scores (t=7.470, 7.538, 10.104,and 7.625, all P<0.05).The Pearson correlation analysis revealed that the fatigue symptom scores were associated with each dimension and the total score of quality of life, and all showed a negative correlation (all P<0.05).Logistic regression analysis showed that age [OR=0.705, 95% confidence interval(CI) 0.555-0.895], tumor grade (OR= 0.503, 95%CI 0.338-0.748), the number of radiotherapy and chemotherapy sessions (OR=0.246, 95%CI 0.131-0.462), KPS score (OR=2.361, 95%CI 1.543-3.612), and fatigue symptoms (OR=0.089, 95%CI 0.031-0.257) were all factors influencing the quality of life of children with glioma (all P<0.05). Conclusions　Children with glioma generally suffer from fatigue symptoms, and this symptom is negatively correlated with the quality of life of the children. Age, tumor grade, number of radiotherapy and chemotherapy sessions, KPS score, and fatigue symptoms are all important factors affecting their quality of life.

Key words:

Glioma, Fatigue, Quality of life, Relevance, Influencing factors, Child

摘要：

目的　探讨胶质瘤患儿多维疲劳量表（MFI-20）症状群评分与生活质量的相关性。方法　采用连续抽样法抽取西安市儿童医院收治的90例胶质瘤患儿，研究时间控制在2019年3月至2024年2月。其中，男42例，女48例，年龄1～16（5.34±1.12）岁。通过MFI-20及欧洲癌症研究与治疗组织的生活质量核心问卷（EORTC QLQ-C30）对患儿的疲劳症状及生活质量进行评估，分析二者之间的相关性。统计学方法采用t检验、单因素、Pearson线性及多因素logistic回归分析。结果　90例患儿中，72例存在疲劳症状，发生率为80.00%，总分为（60.46±5.51）分，生活质量总评分为（67.23±3.89）分；单因素分析显示，不同年龄、肿瘤分级、放化疗次数及KPS评分患儿生活质量总得分差异均有统计学意义（t=7.470、7.538、10.104、7.625，均P<0.05）；Pearson相关性分析得知，疲劳症状得分与生活质量各维度及总分存在关联，均呈负相关（均P<0.05）；logtisic回归分析，结果显示，年龄［OR=0.705，95%置信区间（CI） 0.555～0.895］、肿瘤分级（OR=0.503，95%CI 0.338～0.748）、放化疗次数（OR=0.246，95%CI 0.131～0.462）、KPS评分（OR=2.361，95%CI 1.543～3.612）及疲劳症状（OR=0.089，95%CI 0.031～0.257）均是胶质瘤患儿生活质量的影响因素（均P<0.05）。结论　胶质瘤患儿普遍存在疲劳症状，该症状与患儿生活质量呈负相关，年龄、肿瘤分级、放化疗次数、KPS评分及疲劳症状均是影响其生活质量的重要因素。

关键词:

胶质瘤, 疲劳, 生活质量, 相关性, 影响因素, 儿童