Abstract:

Objective　To explore the clinicopathological characteristics of multiple primary malignant tumors (MPMT). Method　A retrospective analysis was conducted on the clinicopathological data of MPMT patients who visited Xijing Hospital, Air Force Military Medical University from January 2021 to July 2023. Results　Among the 114 patients, there were 42 (36.8%) cases with synchronous MPMT and 72 (63.2%) cases with metachronous MPMT; there were 58 males (50.9%) and 56 females (49.1%); there were 101 cases with dual primary malignant tumors (88.6%), 10 cases with triple primary malignant tumors (8.8%), and 3 cases with quadruple primary malignant tumors (2.6%). The median age was 54 (10, 78) years old at diagnosis with the first primary malignant tumor. We found that the top three types of the first primary malignant tumor were malignant tumors of digestive tract [39.5% (45/114)], head and neck [15.8% (18/114)], and female reproductive system [14.9% (17/114)]; the top three types of the second primary malignant tumor were malignant tumors of digestive tract [36.0% (41/114)], malignant tumors of respiratory system [22.8% (26/114)], and hepatobiliary and pancreatic malignant tumors [17.5% (20/114)]. Eighty-eight patients (77.2%) received surgery, 44 patients (38.6%) received chemotherapy, and 18 patients (15.8%) received radiotherapy for the first primary malignant tumor, respectively. Conclusions　Through clinical feature analysis, we aim to improve our understanding of MPMT. In this paper, the incidence of MPMT in digestive tract is high, and clinical differentiation should be noted.

Key words:

Multiple primary malignant tumors, Synchronous carcinoma, Metachronous carcinoma, Digestive tract

摘要：

目的　分析多原发恶性肿瘤（MPMT）患者的临床病理特征。方法　回顾性收集2021年1月至2023年7月于空军军医大学西京医院诊断为MPMT患者的临床病理资料。结果　共纳入114例MPMT患者，同时性MPMT患者42例（36.8%），异时性MPMT患者72例（63.2%）；男性58例（50.9%），女性56例（49.1%）；双原发恶性肿瘤101例（88.6%），三原发恶性肿瘤10例（8.8%），四原发恶性肿瘤3例（2.6%）。第一原发恶性肿瘤诊断中位年龄54（10，78）岁。第一原发恶性肿瘤中分布占前三位的是消化道［39.5%（45/114）］、头颈部［15.8%（18/114）］和女性生殖系统［14.9%（17/114）］恶性肿瘤。第二原发恶性肿瘤中分布占前三位的是消化道［36.0%（41/114）］、呼吸系统［22.8%（26/114）］和肝胆胰［17.5%（20/114）］恶性肿瘤。第一原发恶性肿瘤接受手术、化疗、放疗分别有88例（77.2%）、44例（38.6%）、18例（15.8%）。结论　通过临床病理特征分析，提高对MPMT的了解，本文中消化道恶性肿瘤发病率高，临床应注意鉴别。

关键词:

多原发恶性肿瘤, 同时性多原发恶性肿瘤, 异时性多原发恶性肿瘤, 消化道