Abstract:

Objective　To investigate the influencing factors of class Ⅱ incision infection after radical operation for non-small cell lung cancer (NSCLC). Methods　Sixty-two patients with class Ⅱ incision infection after radical operation for NSCLC in Ankang Hospital of Traditional Chinese Medicine from March 2018 to March 2022 were retrospectively selected as an infection group, and 85 patients who did not have incision infection were selected as a control group. The clinical data of all the patients were collected, and the influencing factors of class Ⅱ incision infection after radical operation for NSCLC were analyzed by logistic regression analysis. The secretions from the incision of infected patients were collected for pathogen detection. χ² test and independent sample t test were used for statistical analysis. Results　In the infection group, there were 39 males and 23 females, aged (64.29±5.88) years. In the control group, there were 49 males and 36 females, aged (56.74±6.43) years. There was no statistically significant difference in the gender, intraoperative blood loss, smoking history, diabetes, or hypertension between the two groups (all P>0.05). The age in the infection group was older than that in the control group, the operation time was longer than that in the control group, and the proportions of thoracotomy, having visitors, and irrational use of antibiotics were higher than those in the control group (all P<0.05). Multivariate logistic regression analysis showed that age, operation time, operation method, whether there were visitors, and whether antibiotics were used rationally were the influencing factors of class Ⅱ incision infection after radical operation for NSCLC (all P<0.05). Sixty-two patients with class Ⅱ incision infection after radical operation for NSCLC were tested for pathogenic bacteria, and 96 strains were obtained. There were 54 strains of Gram-negative bacteria, accounting for 56.25%, among which Escherichia coli (27 strains, 28.13%) was the main strain; there were 40 strains of Gram-positive bacteria, accounting for 41.67%, among which Staphylococcus aureus (19 strains, 19.79%) was the main strain; there were 2 strains of fungi, accounting for 2.08%. Conclusions　The pathogenic bacteria in patients with class Ⅱ incision infection after radical operation for NSCLC are mainly Gram-negative bacteria. Age, operation time, operation method, whether there are visitors, and whether antibiotics are used rationally are the influencing factors of class Ⅱ incision infection after radical operation for NSCLC.

Key words:

Non-small cell lung cancer, Radical operation, Incision infection, Distribution of pathogenic bacteria, Influencing factors

摘要：

目的　探讨非小细胞肺癌（non-small cell lung cancer，NSCLC）根治术后Ⅱ类切口感染的影响因素。方法　回顾性选取2018年3月至2022年3月于安康市中医医院接受NSCLC根治术后发生Ⅱ类切口感染的62例患者为感染组，另选取NSCLC根治术后未发生切口感染的85例患者为对照组。收集所有患者临床资料，采用logistic回归分析NSCLC根治术后发生Ⅱ类切口感染的影响因素。采集感染组患者切口处分泌物，进行病原菌检测。采用χ²检验、独立样本t检验进行统计学分析。结果　感染组男39例，女23例，年龄（64.29±5.88）岁；对照组男49例，女36例，年龄（56.74±6.43）岁。两组患者性别、术中出血量、吸烟史、糖尿病、高血压差异均无统计学意义（均P>0.05）；感染组患者年龄大于对照组，手术时间长于对照组，开胸手术、有参观人员、未合理使用抗菌药物占比大于对照组（均P<0.05）。多因素logistic回归分析显示，年龄、手术时间、手术方式、是否有参观人员、是否合理使用抗菌药物是NSCLC根治术后发生Ⅱ类切口感染的影响因素（均P<0.05）。对62例NSCLC根治术后发生Ⅱ类切口感染患者进行病原菌检测，得到96株菌株，其中革兰阴性菌54株，占56.25%，以大肠埃希菌（27株，28.13%）为主；革兰阳性菌40株，占41.67%，以金黄色葡萄球菌（19株，19.79%）为主；真菌2株，占2.08%。结论　NSCLC根治术后发生Ⅱ类切口感染的病原菌以革兰阴性菌为主；年龄、手术时间、手术方式、是否有参观人员、是否合理使用抗菌药物均为NSCLC根治术后发生Ⅱ类切口感染的影响因素。

关键词:

非小细胞肺癌, 根治术, 切口感染, 病原菌分布, 影响因素