Abstract:

Objective To investigate the efficacy and safety of ceramide cream in the adjuvant treatment of patients with facial sensitive skin, and to analyze its effect on skin barrier function. Methods　A total of 60 patients with facial sensitive skin who were treated in Department of Dermatology, Guangdong Second Provincial General Hospital from June 2022 to April 2023 were selected for the randomized controlled trial, and were divided into a control group and an observation group by the random number table method, with 30 cases in each group. There were 3 males and 27 females in the control group; they were 22-39 (27.97±4.80) years old; their disease course was 1 week to 5 months. There were 3 males and 27 females in the observation group; they were 19-42 (31.33±6.42) years old; their disease course was 1 week to 5 months. The control group were treated with cetirizine hydrochloride tablets and took anti-sensitivity treatment; in addition, the observation group were treated with ceramide cream. The clinical efficacies, skin cuticle water contents, transepidermal water loss (TEWL), skin oil contents, skin erythema volumes, and incidences of adverse reactions were compared between the two groups by t and χ² tests. Results　The total effective rate in the observation group was higher than that in the control group [96.67% (29/30) vs. 76.67% (23/30)], with a statistical difference (χ²=5.192; P=0.022). Before the treatment and the first week of the treatment, there were no statistical differences in the skin cuticle water content and TEWL between the two groups (all P>0.05). The second and forth week of the treatment, the skin cuticle water contents in the observation group were higher than those in the control group [(159.4±30.38) μs vs. (144.9±24.50) μs and (172.5±27.70) μs vs. (152.8±20.56) μs]; the TEWL's in the observation group were lower than those in the control group [(21.00±3.05) g/m²/h vs. (22.87±2.87) g/m²/h and (18.93±2.98)g/m²/h vs. (21.93±2.73) g/m²/h]; there were statistical differences (t=2.035, 3.128, 2.440, and 4.071; all P<0.05). Before the treatment and the first and second week of the treatment, there were no statistical differences in the skin oil contents and skin erythema volumes between the two groups (all P>0.05). The forth week of the treatment, the skin oil content in the observation group was higher than that in the control group [(5.60±2.39)% vs. (4.13±2.16)%]; the skin erythema volume in the observation group was lower than that in the control group [(12.43±1.76) mm² vs. (14.12±1.79) mm²]; there were statistical differences (t=2.495 and 3.679; both P<0.05). No significant adverse reactions occurred in both groups during the treatment. Conclusion　Ceramide cream has a good auxiliary repair effect on facial sensitive skin, can help reduce the patients' clinical symptoms, has certain application value in promoting the recovery of skin barrier function, and has few adverse reactions and better safety.

Key words:

Sensitive skin, Ceramide cream, Efficacy, Safety, Skin barrier function

摘要：

目的　探究神经酰胺面霜辅助治疗面部敏感性皮肤的修复疗效与安全性，并分析其对皮肤屏障功能的影响。方法　前瞻性研究，选取2022年6月至2023年4月在广东省第二人民医院皮肤科就诊的60例面部敏感性皮肤患者作为研究对象，按照随机数字表法分为对照组和观察组，各30例。对照组男3例、女27例，年龄22～39（27.97±4.80）岁，病程1周～5个月，给予盐酸西替利嗪片和舒敏治疗；观察组男3例、女27例，年龄19～42（31.33±6.42）岁，病程1周～5个月，在对照组基础上加用神经酰胺面霜治疗，均连续治疗4周。对比两组患者临床疗效、治疗前后面部皮肤角质层含水量、经表皮水分流失量（TEWL）、皮肤油脂含量、皮肤红斑量及不良反应发生情况。统计学方法采用t检验、χ²检验。结果　观察组治疗总有效率为96.67%（29/30），高于对照组的76.67%（23/30），差异有统计学意义（χ²=5.192，P=0.022）。治疗前、第1周，两组患者面部皮肤角质层含水量及TEWL比较，差异均无统计学意义（均P>0.05）。第2周、第4周，观察组面部皮肤角质层含水量均高于对照组［（159.4±30.38）μs比（144.9±24.50）μs、（172.5±27.70）μs比（152.8±20.56）μs］，TEWL均低于对照组［（21.00±3.05）g/m²/h比（22.87±2.87）g/m²/h、（18.93±2.98）g/m²/h比（21.93±2.73）g/m²/h］，差异均有统计学意义（t=2.035、3.128、2.440、4.071，均P<0.05）。治疗前、第1周、第2周，两组患者面部皮肤油脂含量及皮肤红斑量比较，差异均无统计学意义（均P>0.05）。第4周，观察组面部皮肤油脂含量高于对照组［（5.60±2.39）%比（4.13±2.16）%］，皮肤红斑量低于对照组［（12.43±1.76）mm²比（14.12±1.79）mm²］，差异均有统计学意义（t=2.495、3.679，均P<0.05）。两组患者在治疗过程中均未出现明显不良反应。结论　神经酰胺面霜对面部敏感性皮肤具有较好的辅助修复疗效，能够减轻患者临床症状，在促进皮肤屏障功能恢复方面具有一定的应用价值，且不良反应少，安全性较佳。

关键词:

敏感性皮肤, 神经酰胺面霜, 疗效, 安全性, 皮肤屏障功能