Research progress on ferroptosis in diabetic kidney disease

doi:10.3760/cma.j.issn.1007-1245.2023.09.003

International Medicine and Health Guidance News ›› 2023, Vol. 29 ›› Issue (9): 1193-1197.DOI: 10.3760/cma.j.issn.1007-1245.2023.09.003

• New Medical Advances • Previous Articles Next Articles

Research progress on ferroptosis in diabetic kidney disease

Cai Rongdan¹, Liu Jianshuai¹, Feng Junxia², Zhang Yunfang², Liu Yunqi¹, Wang Yaning¹

¹Department of Nephrology, Binzhou Medical University Hospital, Binzhou 256600, China; ²Affiliated Huadu Hospital, Southern Medical University, Guangzhou 510800, China

Received:2022-12-25 Online:2023-05-01 Published:2023-05-21
Contact: Wang Yaning, Email: wangyatou122@126.com
Supported by:
National Natural Science Foundation of China (82200758); Project Supported by Key Clinical Discipline Construction Fund of Shandong Province (SLCZDZK-11); Xu Rongxiang Regenerative Medicine Development Program of Binzhou Medical University (BY2020XRX05)

铁死亡在糖尿病肾病中的研究进展

蔡荣丹¹ 刘建帅¹ 冯俊霞² 张云芳² 刘云启¹ 王雅宁¹

¹滨州医学院附属医院肾内科，滨州　256600；²南方医科大学附属花都医院，广州　510800

通讯作者: 王雅宁，Email：wangyatou122@126.com
基金资助:
国家自然科学基金（82200758）；山东省省级临床重点专科学科建设经费项目（SLCZDZK-11）；滨州医学院徐荣祥再生医学发展计划项目（BY2020XRX05）

Abstract

Abstract:

Ferroptosis, a newly discovered non-apoptotic iron-dependent cell death pattern, plays an essential role in the development of acute kidney injury, tumors, liver disease, Parkinson's disease, and other diseases. More recently, it has been shown that ferroptosis is also involved in the development of diabetic kidney disease (DKD). In this paper, we review the mechanism of ferroptosis and its progress in DKD to provide a basis for the regulation using ferroptosis.

Key words:

Diabetic kidney disease, Ferroptosis, Reactive oxygen species, Lipid peroxidation

摘要：

铁死亡是新发现的一种依赖铁的非凋亡性细胞死亡方式，在急性肾损伤、肿瘤、肝病、帕金森病等疾病的发生发展中起着重要作用。近期发现铁死亡也参与了糖尿病肾病（DKD）的发生发展。本文就铁死亡的发生机制及其在DKD中的研究进展进行综述，为利用铁死亡进行调控提供依据。

关键词:

糖尿病肾病, 铁死亡, 活性氧, 脂质过氧化

Cai Rongdan, Liu Jianshuai, Feng Junxia, Zhang Yunfang, Liu Yunqi, Wang Yaning.

Research progress on ferroptosis in diabetic kidney disease [J]. International Medicine and Health Guidance News, 2023, 29(9): 1193-1197.

蔡荣丹刘建帅冯俊霞张云芳刘云启王雅宁.

铁死亡在糖尿病肾病中的研究进展 [J]. 国际医药卫生导报, 2023, 29(9): 1193-1197.

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Research progress on ferroptosis in diabetic kidney disease

铁死亡在糖尿病肾病中的研究进展

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