Abstract:

Objective　To observe the clinical effect of treating patients with migraine under the guidance of "Zang-qi timing theory". Methods　One hundred and twenty-one patients with migraine treated in the outpatient department of Ping'an District Hospital of Traditional Chinese Medicine from January to September 2022 were selected for the prospective study. According to the random number table method, they were randomly divided into a treatment group and a control group. The control group had 18 patients, including 2 males and 16 females; they were (52.23±3.01) years old; they were treated with basic prescriptions. The treatment group were divided into a liver disease group, a heart disease group, a spleen disease group, a lung disease group, and a kidney disease group according to the time rule described in Suwen · Zang-qi Fashi Lun. There were 23 cases in the liver disease group (6 males and 17 females), with an age of (51.34±4.76); there were 19 cases in the heart disease group (3 males and 16 females), with an age of (49.53±5.01); there were 19 cases in the spleen disease group (6 males and 13 females), with an age of (53.14±3.95); there were 20 cases in the lung disease group (4 males and 16 females), with an age of (50.67±4.28); there were 22 cases in the kidney disease group (5 males and 17 females), with an age of (51.97±5.12). The five groups were given different herbs from the five flavors according to the "Wuzang Kuyu Buxie" theory. After 4 weeks' treatment, the pain degrees, durations, and attack times and efficacies were evaluated. The Wilcoxon signed rank test was used for the inter-group comparison. Results　The total effective rate of the treatment group was significantly higher than that of the control group [91.67%(88/96) vs. 68.75%(11/16)], with a statistical difference (χ²=4.964, P<0.05). There was a statistical difference in the score differences of pain severity, duration, and attack times between before and after the treatment between the treatment group and the control group [5.00 (4.00, 6.00) vs. 4.00 (3.00, 5.00), 2.00 (0, 2.00) vs. 0 (0, 1.00), and 4.00 (2.00, 4.00) vs 1.00 (0, 2.00)], with statistical differences (Z=-3.154, -2.648, and -3.860; all P<0.05).  Conclusions　It has a good effect to treat migraine under the guidance of "Zang-qi timing theory". The analysis of this clinical study can provide basis and ideas for the further study of "Zang-qi timing theory".

Key words:

Zang-qi timing theory, Migraine, Huangdi Neijing, Wuzang Kuyu Buxie

摘要：

目的　观察运用脏气法时论指导治疗偏头痛患者的临床疗效。方法　选取2022年1月至9月于海东市平安区中医医院门诊就诊的16～80岁偏头痛患者121例进行前瞻性研究，根据随机数字表法分为治疗组和对照组。对照组18例，男性2例、女性16例，年龄（52.23±3.01）岁，给予基本方治疗。治疗组按照《素问·脏气法时论篇》中所述的时间规律分为肝病组、心病组、脾病组、肺病组和肾病组5组，其中肝病组23例，男性6例、女性17例，年龄（51.34±4.76）岁；心病组19例，男性3例、女性16例，年龄（49.53±5.01）岁；脾病组19例，男性6例、女性13例，年龄（53.14±3.95）岁；肺病组20例，男性4例、女性16例，年龄（50.67±4.28）岁；肾病组22例，男性5例、女性17例，年龄（51.97±5.12）岁。治疗组患者在基本方基础上按照“五脏苦欲补泻”理论加用五味中的不同药物。治疗4周后评价疼痛程度、疼痛持续时间、疼痛发作次数和疗效，组间比较采用Wilcoxon符号秩检验。结果　5组治疗组总有效率为91.67%（88/96），高于对照组68.75%（11/16），差异有统计学意义（χ²=4.964，P<0.05）。在疼痛程度方面治疗组合计的前后积分差值与对照组的前后积分差值比较［5.00（4.00，6.00）分比4.00（3.00，5.00）］，差异有统计学意义（Z=-3.154，P<0.05）；在疼痛持续时间方面治疗组合计与对照组的前后积分差值比较［2.00（0，2.00）分比0（0，1.00）］，差异有统计学意义（Z=-2.648，P<0.05）；在头痛发作次数方面治疗组合计与对照组的前后积分差值比较［4.00（2.00，4.00）分比1.00（0，2.00）］，差异有统计学意义（Z=-3.860，P<0.05）。结论　运用脏气法时论指导治疗偏头痛患者具有良好的效果，可为后续进一步深入研究脏气法时论提供依据和思路。

关键词:

脏气法时论, 偏头痛, 《黄帝内经》, 五脏苦欲补泻