Abstract:

Objective　To explore the efficacy and safety of Yiqi Yangyin Huoxue recipe in the treatment of non-valvular atrial fibrillation. Methods　One hundred and twenty patients with non-valvular atrial fibrillation admitted to Ningyuan County People's Hospital from March 2015 to November 2016 were selected for the study. They were divided into a treatment group and a control group by the random number table method, with 60 cases in each group. There were 33 males and 27 females in the treatment group who were 48-74 (65.00±3.71) years old. There were 36 males and 24 females in the control group who were 43-75 (65.33±2.79) years old. The control group were treated with conventional western medicine, and the treatment group with conventional western medicine and Yiqi Yangyin Huoxue recipe, for 1 month. The curative effects, scores of traditional Chinese medicine syndrome (TCM), coagulation function, and incidences of adverse reactions were compared between the two groups. χ² and t tests were applied. Results　The total effective rate was 98.33% (59/60) in the treatment group, and was 93.33% (56/60) in the control group, with no statistical difference (P>0.05). Before the treatment, there were no statistical differences in TCM syndrome score and coagulation function [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), D-dimer (D-D)] between the two groups (all P>0.05). After one month's treatment, the TCM syndrome score of the treatment group was significantly lower than that of the control group [(3.87±1.43) vs. (5.48±1.74)], with a statistical difference (P<0.05). After one month's treatment, the TT, PT, APTT, D-D level were (14.38±1.37) s, (12.45±0.91) s, (32.50±3.44) s, and (1.82±0.68) mg/L in the treatment group, and were (13.70±1.23) s, (11.27±1.06) s, (30.25±3.51) s, and (2.11±0.77) mg/L in the control group, with statistical differences between the two groups (all P<0.05). The incidence of adverse drug reactions was 6.67% in the treatment group, and was 10.00% in the control group, with no statistical difference (P>0.05). Conclusion　Yiqi Yangyin Huoxue recipe combined with western medicine in the treatment of patients with non-valvular atrial fibrillation is effective and can effectively improve their symptoms and coagulation function and inhibit thrombosis, and does not increase the incidence of adverse reactions, so it is worthy of popularization and application.

Key words:

Atrial fibrillation, Non-valvular, Yiqi Yangyin Huoxue recipe, Coagulation function

摘要：

目的　探究益气养阴活血复方治疗非瓣膜性心房颤动（简称房颤）的有效性和安全性。方法　选择2015年3月至2016年11月宁远县人民医院收治的120例非瓣膜性房颤患者，采用随机数表法将其随机分为治疗组和对照组，各60例。治疗组中，男33例，女27例，年龄48～74（65.00±3.71）岁；对照组中，男36例，女24例，年龄43～75（65.33±2.79）岁。对照组予以常规西药治疗，治疗组在对照组的基础上加用益气养阴活血复方治疗，疗程为1个月。比较两组疗效、治疗前后中医证候积分、凝血功能变化以及不良反应发生率。采用χ²检验、t检验进行统计学分析。结果　治疗组的治疗总有效率为98.33%（59/60），对照组为93.33%（56/60），两组比较，差异无统计学意义（P>0.05）。治疗前，两组中医证候积分、凝血功能指标［凝血酶原时间（PT）、活化部分凝血酶时间（APTT）、凝血酶时间（TT）、D-二聚休（D-D）］水平比较差异均无统计学意义（均P>0.05）。治疗1个月后，治疗组中医证候积分为（3.87±1.43）分，显著低于对照组的（5.48±1.74）分，差异有统计学意义（P<0.05）。治疗后1个月后，治疗组的TT（14.38±1.37）s、PT（12.45±0.91）s、APTT（32.50±3.44）s、D-D（1.82±0.68）mg/L，对照组分别为（13.70±1.23）s、（11.27±1.06）s、（30.25±3.51）s、（2.11±0.77）mg/L，两组比较，差异均有统计学意义（均P<0.05）。治疗组药物不良反应发生率为6.67%（4/60），对照组为10.00%（6/60），差异无统计学意义（P>0.05）。结论　益气养阴活血复方联合西药治疗非瓣膜性房颤效果确切，能够有效改善患者症状和机体凝血功能，有助于抑制血栓形成，且不会增加不良反应，值得推广应用。

关键词:

心房颤动, 非瓣膜性, 益气养阴活血复方, 凝血功能