Abstract:

Objective　To investigate the value of C-reactive protein (CRP)/albumin (ALB) ratio and systemic immune inflammatory index (SII) in the prediction of respiratory failure in patients with Guillain-Barré syndrome (GBS). Methods　A total of 108 patients with GBS who were admitted to Liaocheng Third People's Hospital from May 2018 to May 2022 were selected for the retrospective analysis, including 69 males and 39 females who were (52.15±12.46) years old. They were divided into a respiratory failure group (25 cases) and a pure GBS group (83 cases) according to whether they had respiratory failure during hospitalization. The general clinical data, such as Hughes Functional Classification Scale (HFGS) score at admission and so on, and CRP/ALB and SII at admission were compared between the two groups. t and χ² tests were applied, the combined detection of the two in the prediction of respiratory failure in the GBS patients was analyzed by the receiver operating characteristic curve (ROC). Results　The CRP/ALB and SII at admission in the respiratory failure group were significantly higher than those in the pure GBS group [(3.05±0.35)×10^-3 vs. (2.45±0.31)×10^-3 and (1 453.87±142.65)×10⁹/I vs. (392.75±35.53)×10⁹/I], with statistical differences (both P<0.05). The ROC analysis showed that the area under the ROC of CRP/ALB combined with SII in the prediction of respiratory failure in the GBS patients was higher than those under the ROC's of CRP/ALB and SII (P<0.05). There were statistical differences in HFGS score at admission, cranial nerve involvement, and CRP/ALB and SII at admission between the respiratory failure group and the pure GBS group (all P<0.05). Multivariate logistic analysis showed that HFGS≥3, CRP/ALB ≥ 2.85×10^-3, and SII≥870.52×10⁹/I were important influencing factors for respiratory failure in the GBS patients. Conclusion　The combined detection of CRP/ALB and SII has a high predictive value for respiratory failure in GBS patients.

Key words:

Guillain-Barré syndrome, Respiratory failure, C-reactive protein/albumin ratio, Systemic immune inflammatory index

摘要：

目的　探讨C-反应蛋白（CRP）/白蛋白（ALB）比值及系统免疫炎症指数（SII）对吉兰-巴雷综合征（GBS）患者呼吸衰竭的预测价值。方法　采用回顾性分析，选取2018年5月至2022年5月期间聊城市第三人民医院收治的108例GBS患者作为研究对象，其中，男69例，女39例，年龄（52.15±12.46）岁；根据患者将住院期间是否出现呼吸衰竭将其分为呼吸衰竭组（25例）和单纯GBS组（83例），比较两组患者入院修斯功能分级量表（HFGS）评分等一般临床资料，入院时CRP/ALB比值和SII。采用t、χ²检验，并采用受试者工作特征曲线（ROC）分析二者联合检测对GBS患者发生呼吸衰竭的预测价值。结果　呼吸衰竭组患者入院时的CRP/ALB比值和SII分别为（3.05±0.35）×10^-3、（1 453.87±142.65）×10⁹/I，均明显高于单纯GBS组［（2.45±0.31）×10^-3、（392.75±35.53）×10⁹/I］，差异均有统计学意义（均P<0.05）；ROC分析结果显示，CRP/ALB和SII联合预测GBS患者发生呼吸衰竭的ROC曲线下面积明显比两项指标单独预测更高（P<0.05）。呼吸衰竭组和单纯GBS组在入院时HFGS评分、有无脑神经受累、入院时CRP/ALB比值和SII方面差异均有统计学意义（均P<0.05）；多因素logistic分析结果显示，HFGS≥3分、CRP/ALB≥2.85×10^-3和SII≥870.52×10⁹/I是GBS患者出现呼吸衰竭的重要影响因素。结论　CRP/ALB比值和SII联合检测对于GBS患者呼吸衰竭具有较高的预测价值。

关键词:

吉兰-巴雷综合征, 呼吸衰竭, C-反应蛋白/白蛋白比值, 系统免疫炎症指数