Abstract:

Objective　To investigate the effect of body mass index (BMI) on pregnancy outcomes in young infertile women during intrauterine insemination (IUI) assisted conception, and to shorten treatment course, reduce treatment cost, and improve the clinical pregnancy rate analyzing the remaining effective influencing factors. Methods　The clinical data of the 1st IUI cycle of 1 082 young couples who underwent husband-sperm IUI for pregnancy at Department of Reproductive Medicine, Binzhou Medical University Hospital from September 2016 to August 2022 were retrospectively analyzed. The ages, years of infertility, and levels of follicle-stimulating hormone (FSH) of the normal body weight group (group A), the overweight group (group B), and the obesity group (group C) were compared and analyzed. The relationship between the basic information and the outcomes of IUI for pregnancy in the PCOS/control group was analyzed. The data were compared between the groups by Kruskal-Wallis H test, χ² test, and Fisher's precision probability test. The correlations of the data with the clinical pregnancy rate and live birth rate were analyzed by multivariate logistic regression analysis. Results　There were statistical differences in the age, years of infertility, basal FSH level, natural/propulsive, and PCOS/control between these 3 groups (all P<0.05). There were no statistical differences in the clinical pregnancy rate, live birth rate, and abortion rate between the 3 groups (all P>0.05). The logistic regression analysis of female related factors affecting clinical pregnancy rate and live birth rate of IUI showed that the effects of ovulation promotion treatment on the clinical pregnancy rate and live birth rate were statistically significant (OR=1.564 and 1.619, both P<0.05); the effect of years of infertility on the live birth rate was also statistically significant (OR=0.884, P<0.05). Conclusion　In young infertile women taking IUI assisted conception, BMI does not affect their pregnancy outcomes, but ovulation promotion therapy helps obtain clinical pregnancy and live births, and years of infertility affects the live birth rate.

Key words:

Intrauterine insemination, Live birth rate, Body mass index, Clinical pregnancy rate

摘要：

目的　探讨在宫腔内人工授精（IUI）助孕过程中，体质量指数（BMI）对年轻不孕妇女妊娠结局的影响，并分析其余有效影响因素，以缩短疗程，降低治疗费用，提高临床妊娠率。方法　回顾性分析2016年9月至2022年8月在滨州医学院附属医院生殖中心进行夫精IUI助孕的1 082对年轻夫妇的第1个IUI周期的临床资料，比较分析正常体质量组（A组）、超重组（B组）和肥胖组（C组）患者的年龄、不孕年限、基础卵泡刺激素（FSH）；多囊卵巢综合征（PCOS）/对照等基本资料与IUI助孕结局的关系。组间比较采用Kruskal-Wallis H检验、采用χ²检验或Fisher确切概率法，多因素logistic回归分析各数据与临床妊娠率及活产率的关系。结果　3组间年龄、不孕年限、基础FSH、自然/促排、PCOS/对照差异均有统计学意义（P<0.05）；各组间临床妊娠率、活产率及流产率等妊娠结局指标差异无统计学意义（P>0.05）；影响IUI临床妊娠率、活产率及流产率的女性相关因素logistic回归分析显示，促排卵治疗对临床妊娠率及活产率的影响差异有统计学意义（OR=1.564、1.619，P<0.05）；不孕年限对活产率的影响也具有统计学意义（OR=0.884，P<0.05）。结论　在年轻不孕女性的IUI助孕过程中，BMI不会影响妊娠结局，但是促排卵治疗有助于获得临床妊娠及活产率，同时不孕年限也会影响到活产率。

关键词:

宫腔内人工授精, 活产率, 体质量指数, 临床妊娠率