Abstract:

Pancreatic cancer (PC) is a very common malignant tumor of the digestive system, with obscure onset, high malignancy, and poor prognosis. The pathogenesis of PC is very complex, and many factors play a regulatory role. miRNA is a short strand RNA which does not have coding function, and it can regulate the physiological and pathological functions by directly inhibiting the expression of target genes. A large number of studies have shown that specific miRNAs are abnormally expressed in PC, and these miRNAs play important regulatory roles in the pathogenesis and progression of PC. At the same time, clinical studies have shown that specific miRNAs, as non-invasive biological indicators, also have important potential values in the early diagnosis and clinical prognosis of PC. Scholars have also tried to develop PC therapeutics based on specific miRNAs. Although the results are only basic at present, they still provide an important reference for searching for new PC therapeutics.

Key words:

Pancreatic cancer, miRNA, Diagnosis, Treatment, Prognosis, Progress

摘要：

胰腺癌是十分常见的消化系统恶性肿瘤，具有起病隐匿、恶性度高、临床预后差的特点。胰腺癌的致病机制十分复杂，多种因素在其中发挥调控作用。微RNA（miRNA）是不具有编码功能的短链RNA，其能够通过直接抑制靶基因的表达来发挥对人体生理病理功能的调控。大量的研究证据显示，胰腺癌中存在着大量特异性miRNA的异常表达，且这些miRNA在胰腺癌的致病及进展过程中发挥着重要的调节作用。同时，有临床研究显示，特异性miRNA作为无创生物学指标在用于胰腺癌的早期诊断及临床预后方面也具有重要的潜在价值。学者也尝试开发基于特定miRNA的胰腺癌治疗方法，虽然仅停留在基础研究结果，但是仍为寻找新的胰腺癌治疗方法提供了重要参考。

关键词:

胰腺癌, 微RNA, 诊断, 治疗, 预后, 进展