Abstract:

This paper aimed to summarize the clinical application research progress, feasibility analysis, and mechanism research contents of hyperbaric oxygen chamber therapy synchronous rehabilitation therapy, discuss the existing research results, analyze the feasibility, and determine the next research direction. Literatures on rehabilitation in hyperbaric oxygen chamber was retrieved from CNKI and PubMed databases from January 2006 to December 2022, and the included literatures were analyzed from the aspects of research contents and research methods (experimental design, rehabilitation therapy techniques, research mechanisms, and evaluation methods). According to the research contents of the included literatures, they were roughly divided into 5 different directions according to the function: sports rehabilitation, cognitive rehabilitation, respiratory rehabilitation, musculoskeletal rehabilitation, and rehabilitation nursing. The hyperbaric oxygen in-cabin rehabilitation techniques involved in this study included comprehensive rehabilitation exercise training, motor ideation therapy, occupational cognitive therapy, neuromuscular electrical stimulation, bionic electrical stimulation, right median nerve electrical stimulation, acupuncture, artificial nose, and traction therapy, among which in-cabin physical therapy, occupational therapy, and traditional rehabilitation were the most common. In recent 10 years, the number of such studies had been increasing, and the experimental designs were diverse, including randomized controlled trials and paired trials. The subjects of the studies were mainly common patients in the rehabilitation department, and the curative effect evaluation methods were mainly various rehabilitation evaluation scales. The main mechanisms involved were: ① significantly improving the hemorheological indicators; ② promoting the repair of neurovascular units; ③ enhancing the central nerve plasticity; ④ activating related protease enzymes, growth factors, and triphosadenine (ATP). At present, the quantity and quality of clinical application researches of hyperbaric oxygen chamber rehabilitation therapy need to be improved, the clinical research contents are relatively simple, and the research methods are still in the exploratory stage. Most of the results of these studies focus on the clinical efficacy of dysfunction in the early post-traumatic brain injury and sequelae stage, and it is urgent to reveal the exact mechanism of action of hyperbaric chamber rehabilitation therapy through these studies. The effect of rehabilitation therapy in hyperbaric oxygen chamber still needs to be verified by further clinical mechanism research.

Key words:

Hyperbaric oxygen, Rehabilitation therapy, Occupational therapy, Acupuncture, Rehabilitation in hyperbaric oxygen chamber,  , Progress

摘要：

为总结高压氧舱内治疗同步康复治疗的临床应用研究进展及其可行性分析，探讨已有研究成果、分析可行性以及确立下一步研究方向。检索2006年1月至2022年12月CNKI、PubMed数据库有关在高压氧舱内进行康复治疗研究的文献，对纳入的文献从研究内容和研究方法（试验设计、康复治疗技术、研究机制以及评价方法）进行分析。根据纳入文献研究内容，按照功能大体可分为5个不同方向：运动康复、认知康复、呼吸康复、肌骨康复、康复护理领域。研究涉及的高压氧舱内康复治疗技术包括综合康复运动训练、运动意念治疗、作业认知治疗、神经肌肉电刺激、仿生电刺激、右正中神经电刺激、针刺、人工鼻、牵引治疗，其中以舱内物理治疗、作业疗法、传统康复为多。近10年该类研究数量总体呈增长趋势，试验设计较为多样，以随机对照试验及配对试验设计较多。研究的受试对象以康复科常见患者为主，对于疗效评价方式以各类康复评价量表为主。主要涉及机制：（1）可明显改善血液流变学指标；（2）促进神经血管单元的修复；（3）强化中枢神经可塑性；（4）激活相关蛋白酶、生长因子、三磷酸腺苷。当前高压氧舱内康复治疗的临床应用研究数量及质量有待提升，临床研究内容相对单一，研究方法仍处于探索阶段。研究结果多聚焦于脑卒中、颅脑损伤后早期及后遗症期的功能障碍临床疗效，而亟需通过这些研究揭示高压氧舱内康复治疗的确切作用机制。高压氧舱内康复治疗效果仍需通过进一步的临床机制研究进行验证。

关键词:

高压氧, 康复治疗, 作业治疗, 针刺, 高压氧舱内康复治疗, 进展