Abstract:

Objective　To investigate the status of transesophageal echocardiography (TEE) in the diagnosis of patent foramen ovale (PFO) in middle-young patients with migraine and to evaluate the effect of interventional blocking. Methods　From February to October 2021, 35 middle-young patients suspected with PFO treated at Anyang People's Hospital were selected, including 12 males and 23 females who were (35.4±6.8) years old. Their clinical manifestation was long-term and repeated migraine. All the patients were examined by TEE to observe PFO. Among them, 22 had PFO, and were treated by interventional blocking. Before and after the surgery, the patients were scored by headache impact test-6 (HIT-6) to evaluate the effect. The measurement data of normal distribution were compared by paired t test. Results　Among the 35 patients, 22 patients were diagnosed with PFO by TEE, accounting for 63%. All these 22 patients received interventional blocking. The HIT-6 score was (43.78±4.23) 6 months after the operation, and was (68.59±4.36) before the operation, with a statistical difference (P<0.05). Conclusions　The proportion of middle-aged and young migraine patients complicated with PFO is high. Interventional blocking can effectively improve the clinical symptoms of migraine patients complicated with PFO.

Key words: Migraine, Patent foramen ovale, Transesophageal echocardiography, Interventional blocking

摘要： 目的　探讨经食道超声心动图（transesophageal echocardiography，TEE）对中青年偏头痛患者卵圆孔未闭（patent foramen ovale，PFO）的诊断情况及行导管介入封堵术后效果的评估。方法　选取2021年2月至10月安阳市人民医院收治的35例中青年可疑PFO患者，男12例，女23例，年龄（35.4±6.8）岁，临床表现为长期、反复的偏头痛，均行TEE检查，观察其卵圆孔未闭情况。其中22例患者合并PFO，行介入封堵术治疗，术前及术后6个月对其进行头痛影响测定-6（headache impact test-6，HIT-6）评分，评估PFO介入封堵术的效果。符合正态分布的计量资料采用配对t检验。结果　35例患者中TEE诊断合并PFO者有占63%（22/35），行介入封堵的22例患者术后6个月HIT-6评分为（43.78±4.23）分，较术前的（68.59±4.36）分显著下降，差异有统计学意义（P<0.05）。结论　中青年偏头痛患者合并PFO比例较高，合并PFO的偏头痛患者行介入封堵术能有效改善临床症状。

关键词: 偏头痛, 卵圆孔未闭, 经食道超声, 封堵