Abstract: Objective To observe the effect of hormone in the treatment of renal tubular acidosis caused by Sjogren syndrome, and to summarize nursing measures. Methods Fifty-nine patients with renal tubular acidosis caused by Sjogren syndrome who were admitted in our hospital from July 2017 to July 2019 were selected as the subjects of this study. All patients were treated with low-dose of cyclophosphamide combined with methotrexate, while targeted nursing measureswere carried out. The treatment compliance and adverse reactions (hypokalemia, malnutrition, hypocalcemia) of patients before and after treatment were compared. Results The rate of complications after treatment was 11.9% (7/59), which was lower than that before treatment [40.7% (24/59)] (P<0.05). The treatment compliance after treatment was 98.3% (58/59), which was higher than that before treatment [88.1% (52/59)] (P<0.05). The incidence of adverse reactions was 3.4% (2/59). Conclusion The clinical manifestations of renal tubular acidosis caused by Sjogren syndrome are complicated. The use of low-dose of cyclophosphamide combined with methotrexate treatment, supplemented by targeted nursing measures, can improve the patients' body function and reduce the occurrence of adverse reactions.

Key words: Sjogren syndrome, Renal tubular acidosis, Hormone, Nursing measures

摘要： 目的 观察激素治疗干燥综合征所致肾小管性酸中毒的效果,同时总结护理措施。方法 选取2017年7月至2019年7月本院接诊的干燥综合征所致肾小管性酸中毒患者59例作为本次研究对象,所有患者均采用小剂量环磷酰胺联合甲氨蝶呤治疗,同时开展针对性的护理措施。对比治疗前后患者并发症发生率(低血钾、营养不良、低血钙)以及治疗依从性。结果 治疗后并发症发生率为11.9%(7/59),低于治疗前40.7%(24/59),差异有统计学意义(P<0.05);治疗后依从性为98.3%(58/59),显著高于治疗前88.1%(52/59),差异有统计学意义(P<0.05);59例患者不良反应发生率为3.4%(2/59)。结论 干燥综合征所致肾小管性酸中毒的临床表现复杂,采用小剂量环磷酰胺联合甲氨蝶呤治疗,同时辅以针对性的护理措施能够提高患者的机体功能,减少不良反应发生,降低并发症发生风险,提高患者治疗依从性。

关键词: 干燥综合征, 肾小管性酸中毒, 激素, 护理措施