Abstract: Objective To observe the efficacy and safety of argon knife combined with iodophor pleurodesis by medical thoracoscopy in the treatment of malignant pleural effusion. Methods A total of 54 patients with malignant pleural effusion who were hospitalized in Department of Respiratory and Critical Care Medicine of our hospital from October 2017 to May 2020 were retrospectively analyzed. Among them, 18 patients underwent argon knife combined with iodophor pleurodesis by medical thoracoscopy (observation group), and 36 patients underwent cis-platinum pleurodesis after thoracic closed drainage (control group). The efficiency and safety of the two groups were compared. Results The total effective rates of the observation group and the control group were 94.44% (17/18) and 52.78% (19/36), with statistically significant difference (P<0.01). The adverse reactions rates of the observation group and the control group were 50.00% (9/18) and 41.67% (15/36), without statistically significant difference (P>0.05). Conclusion Argon knife combined with iodophor pleurodesis by medical thoracoscopy has the advantages of high curative effect, high safety, and less adverse reactions in the treatment of malignant pleural effusion, which is worthy of clinical promotion.

Key words: Pleurodesis, Iodophor, Argon knife, Medical thoracoscopy, Pleural effusion

摘要： 目的 观察内科胸腔镜下氩气刀联合碘伏胸膜固定术治疗恶性胸腔积液的疗效及安全性。方法 回顾性分析2017年10月至2020年5月在本院呼吸与危重症医学科住院的54例恶性胸腔积液患者的病例资料,其中18例行胸腔镜下氩气刀联合碘伏胸膜固定术(观察组),36例行胸腔闭式引流后注入顺铂胸膜固定术(对照组),比较两组治疗有效率和安全性。结果 观察组和对照组总有效率分别为94.44%(17/18)和52.78%(19/36),差异有统计学意义(P<0.01)。观察组和对照组不良反应发生率分别为50.00%(9/18)和41.67%(15/36),差异无统计学意义(P>0.05)。结论 内科胸腔镜下氩气刀联合碘伏胸膜固定术治疗恶性胸腔积液具有疗效高、安全性高、不良反应少等优点,值得临床推广。

关键词: 胸膜固定术, 碘伏, 氩气刀, 内科胸腔镜, 胸腔积液