Abstract: Objective To analyze the changes of serum levels of vascular endothelial growth factor (VEGF) in neonates and premature infants with retinopathy with different gestational age. Methods Sixty cases of premature infants with gestational age under 32 weeks who were born in Weifang Maternal and Child Health Hospital from September 2018 to September 2019 were selected as group A, 60 cases of premature infants with gestational age of 32-36 weeks as group B, 60 cases of term infants as group C, 60 cases of term infants with retinopathy of prematurity (ROP) as group D. All were tested for serum VEGF and the results were compared. Results At the first, third, and fifth weeks after birth, the VEGF levels in group D were (523.42±4.45) ng/L, (456.72±3.28) ng/L及(346.23±2.68) ng/L, respectively, which were higher than those in group A [(487.23±3.56) ng/L, (423.48±2.36) ng/L, (301.34±2.13) ng/L], group B [(435.63±3.24) ng/L, (386.32±2.32) ng/L, (250.92±3.22) ng/L], and group C [(245.21±3.21) ng/L, (245.17±3.30) ng/L, (245.06±3.28) ng/L], and those in group A and group B were higher than those in group C, those in group A were higher than those in group B, with statistically significant differences (all P<0.05). There were no statistically significant differences in VEGF levels between neonates with and without oxygen inhalation in group A and C (all P>0.05). At the first, third, and fifth weeks after birth, the VEGF levels of neonates with oxygen inhalation in group B were (330.42±3.28) ng/L, (265.92±3.28) ng/L, (207.56±2.64) ng/L, respectively, which were lower than those of neonates without oxygen inhalation [(334.35±2.79) ng/L, (301.56±2.56) ng/L, (210.24±2.38) ng/L], with statistically significant differences (all P<0.05). The VEGF levels in children with ROP were significantly higher than those in preterm infants, with statistically significant differences (all P<0.05). Conclusion The level of VEGF in children with ROP is higher than that in premature infants, and the smaller the gestational age of premature infants is, the higher the VEGF level is. The increase of VEGF level in premature infants may increase the risk of ROP.

Key words: Neonates, Retinopathy of prematurity (ROP), Vascular endothelial growth factor (VEGF)

摘要： 目的 对不同胎龄新生儿和早产儿视网膜病变(retinopathy of prematurity,ROP)患儿血管内皮生长因子(vascular endothelial growth factor,VEGF)血清水平变化情况进行分析。方法 选取2018年9月至2019年9月于潍坊市妇幼保健院出生的60例<32周早产儿为A组,选择同期出生的60例32~36周的早产儿为B组,选择同期出生的60例足月儿为C组,选择同期出生且存在ROP的60例足月患儿为D组,均予以血清VEGF检测,对比检测结果。结果 出生第1周、第3周、第5周时,D组VEGF水平分别为(523.42±4.45)ng/L、(456.72±3.28)ng/L及(346.23±2.68)ng/L,A组分别为(487.23±3.56)ng/L、(423.48±2.36)ng/L、(301.34±2.13)ng/L,B组分别为(435.63±3.24)ng/L、(386.32±2.32)ng/L、(250.92±3.22)ng/L,C组分别为(245.21±3.21)ng/L、(245.17±3.30)ng/L、(245.06±3.28)ng/L,D组VEGF水平均高于A组、B组、C组,且A组、B组均较C组高,A组较B组高,差异均有统计学意义(均P<0.05);A组、C组有无吸氧新生儿VEGF水平比较差异均无统计学意义(均P>0.05),B组吸氧新生儿出生第1周、第3周、第5周时的VEGF水平分别为(330.42±3.28)ng/L、(265.92±3.28)ng/L、(207.56±2.64)ng/L,均低于未吸氧者的(334.35±2.79)ng/L、(301.56±2.56)ng/L、(210.24±2.38)ng/L,差异均有统计学意义(均P<0.05);ROP患儿各纠正胎龄VEGF水平均较早产儿高,差异均有统计学意义(均P<0.05)。结论 ROP患儿VEGF水平较早产儿高,且早产儿胎龄越小,VEGF水平越高,早产儿VEGF水平上升可能导致ROP发生的风险增大。

关键词: 新生儿, 早产儿视网膜病变, 血管内皮生长因子