Abstract:

Objective　To explore the effects of ureaplasma urealyticum (UU) infection on semen quality and serum sex hormone levels in infertile males. Methods　A total of 102 male infertile patients who were treated at Reproductive Center, Chenggong Hospital Affiliated to Xiamen University from August 2021 to November 2022 and had positive UU tested by real-time fluorescence quantitative polymerase chain reaction were selected as an UU infection group; they were 21-50 years old. One hundred and forty-five males with normal fertility who underwent physical examination in Chenggong Hospital Affiliated to Xiamen University during the same period were selected as a healthy control group; they were 23-48 years old. The semen volumes, pH values, sperm concentrations, sperm motilities, sperm forward movement rates, sperm morphology, and serum sex hormone levels of the two groups were examined and compared. The independent-sample t test was used for the statistical analysis. Results　The sperm concentration, sperm motility, sperm forward movement rate, and percentage of sperm with normal morphology in the UU infection group were lower than those in the healthy control group [(40.38±16.04)×10⁶/ml vs. (51.12±13.39)×10⁶/ml, (36.31±13.75)% vs. (48.15±12.21)%, (29.23±11.54)% vs. (36.21±10.98)%, and (10.86±6.71)% vs. (15.92±10.65)%], with statistical differences (all P<0.05). There were no statistical differences in semen volume, pH, and serum levels of estradiol (E₂), follicle- stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and testosterone (T) between the two groups (all P>0.05). Conclusion　UU infection can decrease the semen quality, and affect the males' fertility.

Key words:

Ureaplasma urealyticum, emen quality, Sperm morphology, Serum sex hormones

摘要：

目的　探讨解脲支原体（ureaplasma urealyticum，UU）感染对不育男性精液质量及血清性激素水平的影响。方法　选取2021年8月至2022年11月期间在厦门大学附属成功医院生殖中心就诊的经实时荧光定量聚合酶链式反应检测UU为阳性的102例男性不育患者为UU感染组，年龄21～50岁；同时收集同期在厦门大学附属成功医院进行健康体检且有正常生育史的男性145例为健康对照组，年龄23～48岁。检测并比较两组研究对象精液量、pH值、精子浓度、精子活率、精子前向运动率、精子形态学及血清性激素水平。统计学分析采用独立样本t检验。结果　UU感染组的精子浓度、精子存活率、精子前向运动率及正常形态精子百分率均明显低于健康对照组［（40.38±16.04）×10⁶/ml比（51.12±13.39）×10⁶/ml、（36.31±13.75）%比（48.15±12.21）%、（29.23±11.54）%比（36.21±10.98）%、（10.86±6.71）%比（15.92±10.65）%］，差异均有统计学意义（均P<0.05）；两组间精液量、pH值及血清雌二醇（estradiol，E₂）、卵泡刺激素（follicle stimulating hormone，FSH）、黄体生成素（luteinizing hormone，LH）、泌乳素（prolactin，PRL）和睾酮（testosterone，T）水平差异均无统计学意义（均P>0.05）。结论　UU感染会使男性精液质量下降，影响男性生育能力。

关键词:

解脲支原体, 精液质量, 精子形态, 血清性激素