Abstract:

In recent years, with the improvement of people's living standards and quality of life, the demand for comfortable medical care has become more urgent, which has also promoted the development of enhanced recovery after surgery (ERAS). ERAS advocates for multimodal analgesia, which involves reducing the use of opioids and enhancing the analgesic effect after surgery through combined anesthesia, combination therapy, and other methods, in order to accelerate the patients' postoperative recovery. Ketamine, as an NMDA (N-methyl-D-aspartate) receptor blocker, has always been used in clinical practice, but some possible adverse reactions limit its further use. With the introduction of esketamine abroad, which has higher potency and fewer adverse reactions, there are still few relevant clinical trials in China, and there is still a lack of sufficient clinical trials to verify its safety and effectiveness. Anesthesiologists still have doubts and concerns about its use. Therefore, this article systematically discusses the common application of esketamine in department of anesthesia, in order to provide some support and reference.

Key words:

Esketamine, Painless examination, Postoperative analgesia, Clinical Anesthesia, Progress

摘要：

近年来，随着人民生活水平的提高和生活质量的改善，对舒适化医疗的需求更加迫切，这也促进了加速康复外科（enhanced recovery after surgery，ERAS）的发展。ERAS倡导多模式镇痛，即通过联合麻醉、复合用药等方式，减少阿片类药物的使用量，并增强术后的镇痛效果，以期加快患者的术后康复。而氯胺酮作为N-甲基-D-天（门）冬氨酸（NMDA）受体阻滞药，在临床上一直有应用，但可能存在的一些不良反应限制了它的进一步使用。随着国外效价更高、不良反应更少的艾司氯胺酮的引入，国内相关临床试验还较少，尚缺少充足的临床试验对其安全性及有效性进行验证，麻醉医生对其使用还存在疑问和顾虑，故本文对艾司氯胺酮在麻醉科的常见应用进行系统论述，旨在提供部分支持和参考。

关键词:

艾司氯胺酮, 无痛检查, 术后镇痛, 临床麻醉, 进展