A case of acute severe liver injury caused by Puyuanhewei capsules

doi:10.3760/cma.j.issn.1007-1245.2023.22.015

International Medicine and Health Guidance News ›› 2023, Vol. 29 ›› Issue (22): 3205-3208.DOI: 10.3760/cma.j.issn.1007-1245.2023.22.015

• Case Report • Previous Articles Next Articles

A case of acute severe liver injury caused by Puyuanhewei capsules

He Xiangqin¹, Zhang Junhua², Yang Fang¹, Ding Guofeng¹

¹Department of Infectious Diseases, Binzhou Medical University Hospital, Binzhou 256600, China; ²Binzhou Center for Adverse Drug Reaction Monitoring, Binzhou 256600, China

Received:2023-06-12 Online:2023-11-15 Published:2023-11-23
Contact: Yang Fang, Email: yangfang.168@163.com
Supported by:
Project of Shandong Center for Adverse drug reaction Monitoring (2022SDADRKY28)

蒲元和胃胶囊致急性重度肝损伤1例

何祥琴¹ 张军华² 杨芳¹ 丁国锋¹

¹滨州医学院附属医院感染科，滨州　256600；²滨州市药品不良反应监测中心，滨州　256600

通讯作者: 杨芳，Email： yangfang.168@163.com
基金资助:
山东省药品不良反应监测中心委托项目（2022SDADRKY28）

Abstract

Abstract:

The clinical data of a patient with severe liver injury caused by Puyuanhewei capsules for chronic atrophic gastritis in Binzhou Medical University Hospital were retrospectively analyzed. The causal relationship between Puyuanhewei capsules and liver injury was evaluated according to the Roussel Uclaf assessment method (RUCAM). Through document retrieval, the components that may cause liver injury in Puyuanhewei capsules were analyzed, and it was found that the possible pathogenic components were corydalis Yanhusuo and Taraxacum. The purpose is to remind clinicians to closely monitor the patients' liver function when using Puyuanhewei capsules and traditional Chinese patent medicines and simple preparations containing corydalis Yanhusuo, and to stop using the drug in time after serious liver damage occurs.

Key words:

Liver injury, Puyuanhewei capsules, Chinese medicines, Yanhusuo, Adverse drug reactions

摘要：

回顾性分析滨州医学院附属医院１例服用蒲元和胃胶囊治疗慢性萎缩性胃炎致重度肝损伤的患者的临床资料，采用Roussel Uclaf因果关系评估法（the Roussel Uclaf assessment method，RUCAM）^［¹^］对蒲元和胃胶囊与肝损伤的因果关系进行评估，通过文献检索对蒲元和胃胶囊中可能致肝损伤的组分进行分析，发现可能的致病组分为延胡索、蒲公英，旨在提醒临床医生在应用蒲元和胃胶囊及含有延胡索的中成药时，需密切监测患者肝功能，发生严重肝损伤后应及时停药。

关键词:

肝损伤, 蒲元和胃胶囊, 中成药, 延胡索, 药物不良反应

He Xiangqin, Zhang Junhua, Yang Fang, Ding Guofeng.

A case of acute severe liver injury caused by Puyuanhewei capsules [J]. International Medicine and Health Guidance News, 2023, 29(22): 3205-3208.

何祥琴张军华杨芳丁国锋.

蒲元和胃胶囊致急性重度肝损伤1例 [J]. 国际医药卫生导报, 2023, 29(22): 3205-3208.

References

[1] Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update [J]. Int J Mol Sci, 2015, 17(1):14. DOI: 10.3390/ijms17010014.
[2] 桂月,张彦丽,张谦,等.101例中药相关性肝损伤不良反应报表分析[J].北京中医药,2020,39(4):392-394. DOI:10.16025/j.1674-1307.2020.04.028.
[3] 刘丽艳,唐晓雯,胡丽,等.113例药物性肝损伤的回顾性分析[J].肝脏,2020,25(04):387-389. DOI:10.14000/j.cnki.issn.1008-1704.2020.04.019.
[4] Li C, Tan J, Zhang G, et al. Risk factors of hyperthyroidism with hepatic function injury: a 4-year retrospective study[J].Horm Metab Res,2015,47:209-213. DOI:10.1055/s-0034-1375690.
[5] 中华中医药学会肝胆病分会,中华中医药学会中成药分会. 中草药相关肝损伤临床诊疗指南[J]. 临床肝胆病杂志,2016,32(5):835-843. DOI:10.3969/j.issn.1001-5256. 2016.05.003.
[6] Hsieh A, Adelstein S, McLennan SV, et al. Liver enzyme profile and progression in association with thyroid autoimmunity in Graves' disease[J]. Endocrinol Diabetes Metab, 2019, 2(4): e00086. DOI:10.1002/edm2.86.
[7] Elias RM, Dean DS, Barsness GW. Hepatic dysfunction in hospitalized patients with acute thyrotoxicosis: a decade of experience[ J]. ISRN Endocrinol, 2012: 325092.11. DOI:10.5402/2012/325092.
[8] Papachristos DA, Huynh J, Grossman M, et al. Liver dysfunction and anti-thyroid therapy[J].SAGE Open Med Case Rep, 2015, 3: 2050313X14568335. DOI:10.1177/2050313X14568335.
[9] Piantanida E, Ippolito S, Gallo D, et al. The interplay between thyroid and liver: implications for clinical practice [J]. J Endocrinol Invest, 2020, 43(8): 885-899.DOI:10.1007/s40618-020-01208-6.
[10] 毕婷婷,林庆焕,李晓帆,等.甲状腺功能亢进应用丙硫氧嘧啶联合比索洛尔治疗对患者TSH和TBil水平的影响[J]. 国际医药卫生导报, 2021, 27(17): 2735-2738. DOI: 10.3760/cma.j.issn.1007-1245. 2021.17.024.
[11] Shen T, Liu Y, Shang J, et al. Incidence and etiology of drug-induced liver injury in mainland China [J]. Gastroenterology, 2019, 156(8): 2230-2241. DOI:10.1053/j. gastro.2019.02.002.
[12] 杨全军,陈力,陈林林,等. 中成药致急慢性肝损伤的原因析要及防范[J]. 世界华人消化杂志,2018,26(21):1273-1279. DOI:10.11569/wcjd.v26.i21.1273.
[13] 刘传梦,方静,王元霞,等.中草药相关肝损伤机制研究进展[J]. 中华中医药学刊,2020,38(6):177-181. DOI: 10.13193/j.issn.1673-7717.2020.06.042.
[14] 丁宝明,朱银顿,李庆茂. 蒲元和胃胶囊联合雷贝拉唑治疗慢性萎缩性胃炎的效果观察[J]. 中国医药科学,2022,12(18):74-77. DOI:10.3969/j.issn.2095-0616. 2022.18.019.
[15] 杨瑞华,李芹.复方枣仁胶囊致肝损害1例[J].内蒙古中医药,2014,33(13):83. DOI:10.16040/j.cnki.cn15-1101. 2014.13.174.
[16] 陈淑华,黄贤亮. 妇炎舒胶囊致药物性肝损害1例[J]. 中成药,2021,43(2):566-567. DOI:10.3969/j.issn.1001- 1528.2021.02.058.
[17] 栾小艺,王晖,解斐.1例蒲公英致化疗患者药物性肝损伤的药学监护实践与分析[J]. 药学研究,2022,41(3):206-208. DOI: 10.13506/j.cnki.jpr.2022.03.015.
[18] 陶艳慧,汪佳兵.可达灵片诱导肝损伤8例[J]. 中国乡村医药,2021,28(4):34. DOI:10.19542/j.cnki.1006-5180. 004881.
[19] 何婷婷,钟学文,张宁,等.187例中草药及其制剂导致肝损伤病例前瞻性临床研究[J].肝脏,2018,23(08):666-669. DOI: 10.14000/j.cnki.issn.1008-1704.2018.08.007.
[20] 朱云,李永纲,王葽,等. 595例中药导致肝损伤临床特征分析[J]. 中国中西医结合杂志,2016,36(1):44-48. DOI:10.7661/CJIM.2016.01.0044.
[21] 黄泰康,丁至遵,赵守训,等.现代本草纲目[M].北京: 中国医药科技出版社, 2000: 1063-1066.
[22] 杜伟锋,孙海英,洪浩,等.基于谱效关系的醋延胡索炮制前后特征成分研究[J].中草药,2021,52(20):6178-6187.
[23] 闵清,白育庭,舒思洁,等. 延胡索乙素对四氯化碳致小鼠肝损伤的保护作用[J]. 中国中药杂志,2006,31(6):483-484,521. DOI:10.3321/j.issn:1001-5302.2006.06.013.
[24] 颜晶晶,俸珊,何丽娜,等. 延胡索乙素对映体对人肝微粒体细胞色素P450酶抑制作用机制研究[J]. 中草药,2015,46(4):534-540. DOI:10.7501/j.issn.0253-2670. 2015.04.014.
[25] 吕渭升. 基于FXR的蒲公英乙酸乙酯提取物利胆作用研究[D].广州:广州中医药大学,2015.

A case of acute severe liver injury caused by Puyuanhewei capsules

蒲元和胃胶囊致急性重度肝损伤1例

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