Abstract:

Macrophages is one of the important immune cells involved in the body immune response. With the deepening of research on macrophages, the concept of tumor-associated macrophages (TAMs) has been proposed. TAMs are complex and heterogeneous cell groups in the tumor microenvironment (TME); they are closely related to the occurrence of tumor-related inflammation; they can affect tumor growth, invasion, metastasis, and angiogenesis. TAMs can also secrete a variety of cytokines and chemokines to inhibit the occurrence of anti-tumor immune response. TAMs are closely related to the occurrence and development of tumors. Therefore, They become interesting targets for tumor therapy. This review focuses on the origin and polarization of TAMs, their involvement in tumor progression, metabolism, epigenetic regulation, and their clinical use as targets for tumor therapy.

Key words:

Tumor associated macrophages, Tumor microenvironment, Targeted therapy

摘要：

巨噬细胞是机体内参与免疫反应的重要免疫细胞之一，随着人们对巨噬细胞研究的深入，肿瘤相关巨噬细胞（TAMs）这一概念被提出。TAMs是肿瘤微环境（TME）中复杂而异质的细胞群，与肿瘤相关炎症的发生有密切关系，可影响肿瘤的生长、侵袭、转移和肿瘤内血管形成，也可分泌多种细胞因子和趋化因子抑制抗肿瘤免疫反应的发生。由此可见，TAMs与肿瘤的发生发展有密切的关系，因此成为肿瘤治疗的有趣靶点。本文就TAMs如何参与肿瘤进展、如何在临床中用于肿瘤治疗的靶点进行综述。

关键词:

肿瘤相关巨噬细胞, 肿瘤微环境, 靶向治疗