Abstract:

Objective　To investigate the correlations between the levels of glycosylated hemoglobin (HbA1c) and C-peptide (C-P) and type 2 diabetic peripheral neuropathy. Methods　From February 2020 to January 2022, 96 patients with type 2 diabetes were diagnosed by coronary angiography in Jinan Second People's Hospital, including 26 cases of simple type 2 diabetes and 70 cases of type 2 diabetic peripheral neuropathy. Another 32 healthy people were selected as the healthy group. In the simple type 2 diabetes group, there were 12 males and 14 females, aged 32-68 (55.26±7.14) years; in the type 2 diabetic peripheral neuropathy group, there were 32 males and 38 females, aged 30-67 (53.24±7.14) years; in the healthy group, there were 20 males and 12 females, aged 30-76 (58.25±7.69) years. The patients' clinical data were collected and compared. The levels of HbA1c and C-P were determined. Spearman method was used to analyze the correlations between HbA1c and C-P levels and type 2 diabetic peripheral neuropathy. t test and F test were used for the measurement data and χ² test for the count data. Results　The levels of HbA1c [(7.37±0.87) % and (8.52±0.96) %] and C-P [(5.63±1.67) μg/L and (7.14±1.84) μg/L] in the type 2 diabetes group and the type 2 diabetic peripheral neuropathy group were higher than those in the healthy group [(7.02±0.68) % and (3.12±1.53) μg/L], with statistically significant differences (both P<0.05). There were no statistically significant differences in the general data such as gender, age, body weight, course of disease, hypertension, smoking, drinking, fasting blood glucose, and heart rate between the two groups of type 2 diabetic patients (all P>0.05). Spearman correlation analysis showed that C-P and HbA1c levels were positively correlated with type 2 diabetic peripheral neuropathy (r=0.895, 0.870; P=0.010, 0.016). Conclusions　The levels of HbA1c and C-P are abnormal in patients with type 2 diabetic peripheral neuropathy. The levels of HbA1c and C-P are related to type 2 diabetic peripheral neuropathy, which can provide some references for guiding clinical early diagnosis and early prevention and treatment of type 2 diabetic peripheral neuropathy.

Key words:

Glycosylated hemoglobin, C-peptide, Type 2 diabetic peripheral neuropathy

摘要：

目的　探讨糖化血红蛋白（HbA1c）、C肽（C-P）水平与2型糖尿病周围神经病变的关联性。方法　回顾性分析2020年2月至2022年1月济南市第二人民医院行冠脉造影检查结果诊断为2型糖尿病患者96例（单纯2型糖尿病26例、2型糖尿病周围神经病变70例），另选取32例健康者为健康组。单纯2型糖尿病组男12例、女14例，年龄32～68（55.26±7.14）岁；2型糖尿病周围神经病变组男32例、女38例，年龄30～67（53.24±7.14）岁；健康组男20例、女12例，年龄30～76（58.25±7.69）岁。收集并比较患者临床资料；测定HbA1c、C-P水平；采用Spearman法分析HbA1c、C-P水平与2型糖尿病周围神经病变的相关性。计量资料采用t检验、F检验，计数资料采用χ²检验。结果　单纯2型糖尿病组、2型糖尿病周围神经病变组患者HbA1c水平［（7.37±0.87）%、（8.52±0.96）%］、C-P水平［（5.63±1.67）μg/L、（7.14±1.84）μg/L］均高于健康组［（7.02±0.68）%、（3.12±1.53）μg/L］，差异均有统计学意义（均P<0.05）。两组2型糖尿病患者性别、年龄、体质量、病程、高血压、吸烟、饮酒、空腹血糖、心率等一般资料比较，差异均无统计学意义（均P>0.05）。Spearman相关性分析结果显示，C-P、HbA1c与2型糖尿病周围神经病变呈正相关（r=0.895、0.870，P=0.010、0.016）。结论　2型糖尿病周围神经病变患者HbA1c、C-P水平异常，HbA1c、C-P水平与2型糖尿病周围神经病变相关，可为指导临床早期诊断2型糖尿病周围神经病变并及早进行防治提供一定参考。

关键词:

糖化血红蛋白, C肽, 2型糖尿病周围神经病变