Abstract:

Objective　To compare the effects of lipid-soluble and water-soluble iodine contrast agents (iodine oil and iodine water) on the image quality of hysterosalpingography (HSG) digital radiology (DR) and postoperative pregnancy rate in infertile women. Methods　The subjects were all infertility patients who visited the infertility clinic in the Reproductive Medicine Center of The Sixth Affiliated Hospital of Sun Yat-Sen University from June 2014 to June 2018. A total of 625 patients underwent HSG examination with complete imaging and clinical data, including 124 patients in the iodine oil group and 501 patients in the iodine water group, and the patients were followed up for 6-12 months after HSG. The median age of the iodine oil group was 29.0 years old and the median infertility time was 22.5 months; the median age of the iodine water group was 30.0 years old and the median infertility time was 21.5 months. The excellent and good rate of HSG image quality and follow-up pregnancy rate were compared between the two groups. Chi-square test was used. Results　Two kinds of agents for HSG had obtained the good images. The excellent and good rate of HSG image quality in the iodine oil group was 95.97% (119/124), and there was no statistically significant difference compared with that in the iodine water group [95.41% (478/501)] (χ²=0.072, P=0.788). The postoperative pregnancy rate of the iodine oil group was 38.71% (48/124), and there was no statistically significant difference compared with that in the iodine water group [37.92% (190/501)] (χ²=0.026, P=0.872). The iodine oil contrast agent made the uterine cavity more defined, and the iodine water contrast agent showed more details of the fallopian tube. No serious complications occurred in either case. Conclusion　Lipid-soluble and water-soluble iodine contrast agents for HSG have no significant effects on diagnostic images and postoperative pregnancy rate.

Key words: Hysterosalpingography, Iodine contrast agent, Pregnancy rate

摘要： 目的　比较脂溶性碘对比剂（碘油）和水溶性碘对比剂（碘水）对不孕症妇女子宫输卵管造影（HSG）数字化X线摄影（DR）图像质量和术后妊娠率的影响。方法　研究对象均来源于中山大学附属第六医院生殖医学中心2014年6月至2018年6月在不孕症门诊就诊的不孕症患者。共625例进行了HSG检查，并具有完整的影像、临床资料，其中碘油组124例、碘水组501例，HSG后随访6～12个月。碘油组中位年龄29.0岁，中位不孕时间22.5个月；碘水组中位年龄30.0岁，中位不孕时间21.5个月。比较两组HSG的显影质量优良率和随访妊娠率。采用χ²检验。结果　2种对比剂HSG均获得了较好的图像。碘油组HSG影像优良率95.97%（119/124），与碘水组［95.41%（478/501）］比较，差异无统计学意义（χ²=0.072，P=0.788）。碘油组术后妊娠率为38.71%（48/124），与碘水组［37.92%（190/501）］比较，差异无统计学意义（χ²=0.026，P=0.872）。碘油对比剂使宫腔轮廓更加清晰，碘水对比剂显示更多的输卵管细节，二者均未引起严重并发症。结论　常规HSG使用碘油和碘水对比剂，对诊断影像和术后妊娠率无明显影响。

关键词: 子宫输卵管造影, 碘对比剂, 妊娠率