Abstract: Objective　To explore the effect of loratadine combined with sphenopalatine ganglion acupuncture on allergic rhinitis (AR). Methods　Seventy-one AR patients admitted to Second Hospital of Tianjin Medical University from May 2020 to January 2022 were selected for the prospective study, including 37 males and 34 females, with an age of (37.99±19.51) years old. The patients were divided into group A (39 cases) and group B (32 cases) according to the therapeutic methods. Group A was treated with loratadine, and group B was treated with sphenopalatine ganglion acupuncture on the basis of group A. The clinical efficacy and changes of related cytokines in the two groups were observed, the data were analyzed with SPSS 20.0 statistical software, and χ² test and independent sample t test were used. Results　After treatment, the total syndrome score of TCM in group B was (4.86±0.89), which was lower than that in group A (7.32±1.06) (t=10.447, P<0.001). The total effective rate in group B was 84.38% (27/32), which was higher than 58.97% (23/39) in group A (χ²=4.991, P=0.027). The overall score of quality of life in group B was (9.15±2.12), which was lower than that in group A (14.75±1.93) (t=11.637, P<0.001). The levels of interleukin (IL)-4, IL-10, interferon (INF)-γ, and Th1/Th2 in group B after treatment were (10.27±0.51) ng/L, (7.55±0.67) ng/L, (18.22±0.23) ng/L, and (13.14±0.46)%, those in group A were (12.11±0.31) ng/L, (9.85±0.53) ng/L, (20.92±0.14) ng/L, and (15.78±0.22)%, and the levels of all cytokines in group B were lower than those in group A (all P<0.05). Conclusion　In the treatment of AR patients, compared with conventional single western medicine, sphenopalatine ganglia acupuncture combined with loratadine has a good clinical effect, which is beneficial to regulate the levels of related cytokines and improve the quality of daily life.

Key words: Acupuncture therapy, Sphenopalatine ganglia, Loratadine, Allergic rhinitis, Helper T cells, Interferon gamma

摘要： 目的　探析氯雷他定复合针刺蝶腭神经节治疗变应性鼻炎（AR）的效果。方法　选择2020年5月至2022年1月天津医科大学第二医院收治的AR患者71例进行前瞻性研究，其中男性37例，女性34例，年龄（37.99±19.51）岁。按治疗方法将其分成A组（39例）和B组（32例），A组给予氯雷他定治疗，B组则在A组的基础上联合针刺蝶腭神经节治疗，观察两组临床疗效及相关细胞因子变化情况，并使用SPSS 20.0统计软件分析数据，采用χ²检验、独立样本t检验。结果　治疗后B组中医总症候积分为（4.86±0.89）分，低于A组的（7.32±1.06）分（t=10.447，P<0.001）；B组治疗总有效率为84.38%（27/32），高于A组的58.97%（23/39）（χ²=4.991，P=0.027）；B组生活质量总得分为（9.15±2.12）分，低于A组的（14.75±1.93）分（t=11.637，P<0.001）；B组治疗后白细胞介素（IL）-4、IL-10、干扰素（INF）-γ、Th1/Th2水平分别为（10.27±0.51）ng/L、（7.55±0.67）ng/L、（18.22±0.23）ng/L、（13.14±0.46）%，A组分别为（12.11±0.31）ng/L、（9.85±0.53）ng/L、（20.92±0.14）ng/L、（15.78±0.22）%，B组各项细胞因子水平均低于A组（均P<0.05）。结论　在针对AR患者的治疗中，与常规单一西药治疗相比，针刺蝶腭神经节联合氯雷他定临床应用效果良好，有利于调节相关细胞因子水平，提高患者日常生活质量。

关键词: 针刺疗法, 蝶腭神经节, 氯雷他定, 变应性鼻炎, 辅助性T细胞, 干扰素γ