Abstract: Objective　To analyze the off-label use of omeprazole in pediatric outpatient department in Guangdong Women and Children's Hospital, and to provide references for promoting clinical rational drug use. Method　Retrospective analysis method was used to collect and analyze the relevant medication data of omeprazole in pediatric outpatient department of Guangdong Women and Children's Hospital from March to October 2020. Results　A total of 930 prescriptions were collected and reviewed. The medication in these prescriptions were mainly taken orally (921 cases, 99.03%). Omeprazole was mainly used to treat acute and chronic gastritis [51.40% (478/930)], Helicobacter pylori infection [22.26% (207/930)], and dyspepsia [11.29% (105/930)]. There were 746 prescriptions for omeprazole combination medication with antibiotics (279 cases, 37.40%), gastric mucosal protectants (151 cases, 20.24%), probiotics (143 cases, 19.17%) and so on. Conclusions　Over indication medication and over applicable groups medication were main types of off-label use of omeprazole in pediatric outpatient department of Guangdong Women and Children's Hospital. The usage was basically conformed to the requirements of evidence-based medicine. These prescriptions including dosages, diagnoses, and medication regimens were judged to be reasonable. Doctors and pharmacists should work together to promote the rational use of omeprazole to ensure safe and effective drug use for children.

Key words: Pediatric outpatient department, Omeprazole, Proton pump inhibitors, Off-label use

摘要： 目的　对广东省妇幼保健院儿科门诊奥美拉唑的超说明书应用状况进行分析，为儿童合理使用奥美拉唑提供临床参考。方法　采用回顾性调查方法，对2020年3月至10月广东省妇幼保健院儿科门诊使用奥美拉唑的相关用药数据进行收集、统计分析。结果　收集和审查儿科门诊使用奥美拉唑制剂的处方共930张，以口服剂型为主（921张，99.03%）；在使用奥美拉唑制剂处方中，治疗疾病分类排名前3位分别为奥美拉唑制剂主要用于治疗急、慢性胃炎［51.40%（478/930）］、幽门螺旋杆菌感染［22.26%（207/930）］和消化不良［11.29%（105/930）］。联合用药处方746张，奥美拉唑与抗菌药物（279张，37.40%）、胃黏膜保护剂（151张，20.24%）和微生态制剂（143张，19.17%）联合使用。结论　奥美拉唑在广东省妇幼保健院儿科门诊的超说明书用药主要为超适应人群和超适应证用药的类型，用法符合循证医学要求，处方的治疗范围和给药方案均合理。医生与药师应共同推进奥美拉唑制剂的合理使用，使儿童用药安全、有效。

关键词: 儿科门诊, 奥美拉唑, 质子泵抑制剂, 超说明书用药