Abstract: Objective　To investigate the androgen level and incidence of postoperative urinary incontinence in patients with early prostate cancer treated by laparoscopic radical prostatectomy. Methods　A total of 102 patients with early prostate cancer admitted to Affiliated Hospital of Jiangnan University from October 2020 to October 2022 were selected, and were divided into a conventional group (51 cases) and an observation group (51 cases) by the random number table. The age of the observation group was (56.85±10.26) years old, and that of the conventional group was (57.25±11.25) years old. The conventional group was treated with open radical prostatectomy, while the observation group was treated with laparoscopic radical prostatectomy. The surgery-related indicators, androgen (free testosterone and dihydrotestosterone) levels, and incidence of postoperative urinary incontinence were compared between the two groups. t test was used for the measurement data, and chi-square test was used for the count data. Results　The intraoperative blood loss of the observation group was lower than that of the conventional group, and the operation time and postoperative extubation time of the observation group were shorter than those of the conventional group (all P<0.05). There were no statistically significant differences in the preoperative free testosterone and dihydrotestosterone levels between the two groups (both P>0.05); the levels of free testosterone and dihydrotestosterone in the two groups after surgery were lower than those before surgery, but those in the observation group were higher than those in the conventional group (all P<0.05). The incidence of postoperative urinary incontinence in the observation group [5.88% (3/51)] was lower than that in the conventional group [19.61% (10/51)] (P<0.05). Conclusion　Laparoscopic radical prostatectomy for early prostate cancer is helpful to improve the surgical indicators, increase the androgen level, and reduce the incidence of postoperative urinary incontinence, which is worth popularizing.

Key words: Early prostate cancer, Radical prostatectomy for early prostate cancer, Free testosterone, Dihydrotestosterone, Postoperative urinary incontinence

摘要： 目的　探究早期前列腺癌患者应用腹腔镜前列腺癌根治术治疗的雄激素水平及术后尿失禁发生率。方法　选取江南大学附属医院2020年10月至2022年10月收治的102例早期前列腺癌患者，随机数字表法分为常规组51例和观察组51例。观察组年龄（56.85±10.26）岁，常规组年龄（57.25±11.25）岁。常规组行开放性前列腺癌根治术治疗，观察组行腹腔镜前列腺癌根治术。比较2组患者手术相关指标，雄激素（游离睾酮及双氢睾酮）水平，术后尿失禁发生率。计量资料采用t检验，计数资料采用χ²检验。结果　观察组术中出血量低于常规组，观察组手术时间、术后拔管时间短于常规组（均P<0.05）。2组患者术前游离睾酮、双氢睾酮水平比较差异均无统计学意义（均P>0.05）；2组患者术后的游离睾酮、双氢睾酮较术前均降低，但观察组高于常规组（均P<0.05）。观察组患者的术后尿失禁发生率［5.88%（3/51）］低于常规组［19.61%（10/51）］（P<0.05）。结论　腹腔镜前列腺癌根治术治疗早期前列腺癌，有助于改善手术指标，提高雄激素水平，降低术后尿失禁发生率，值得推广。

关键词: 早期前列腺癌, 早期前列腺癌根治术, 游离睾酮, 双氢睾酮, 术后尿失禁