Correlations between serum angiotensin Ⅱ and tumor necrosis factor-α levels and
myocardial reperfusion injury after heart valve replacement

doi:10.3760/cma.j.issn.1007-1245.2022.16.024

Abstract

Abstract:

Objective　To analyze the relationships between serum angiotensin Ⅱ (AngⅡ) and tumor necrosis factor-α (TNF-α) levels and myocardial reperfusion injury in patients after heart valve replacement. Methods　A total of 119 patients with rheumatic heart disease who underwent heart valve replacement in Jiamusi Central Hospital from June 2015 to June 2021 were selected, including 78 males and 41 females, aged (72.57±3.42) years. The levels of serum AngⅡ and TNF-α in all patients were measured before heart valve replacement, and the levels of serum cardiac troponin T (cTnT) and creatine kinase (CK) were measured 24 hours after operation. Pearson correlation analysis was used to analyze the correlations between serum AngⅡ and TNF-α levels and myocardial reperfusion injury indexes (serum cTnT and CK) in patients after heart valve replacement. Results　The levels of serum AngⅡ, TNF-α, cTnT, and CK in the 119 patients with rheumatic heart disease were (128.64±14.38) ng/dl, (38.67±4.52) fmol/ml, (1.26±0.28) μg/L, and (267.52±10.54) U/L. Pearson correlation analysis showed that serum AngⅡ and TNF-α were positively correlated with serum cTnT and CK levels in the patients after heart valve replacement (all r>0, P<0.05). Conclusion　The levels of serum AngⅡ and TNF-α are closely related to myocardial reperfusion injury in patients after heart valve replacement.

Key words: Rheumatic heart disease, Heart valve replacement, Myocardial reperfusion injury, Angiotensin Ⅱ, Tumor necrosis factor-α

摘要： 目的　分析血清血管紧张素Ⅱ（AngⅡ）、肿瘤坏死因子-α（TNF-α）与心脏瓣膜置换术后患者心肌再灌注损伤的关系。方法　选取佳木斯市中心医院2015年6月至2021年6月行心脏瓣膜置换术治疗的119例风湿性心脏病患者，男78例、女41例，年龄（72.57±3.42）岁，所有患者均于心脏瓣膜置换术前测定血清AngⅡ、TNF-α水平，术后24 h测定患者血清心肌肌钙蛋白T（cTnT）、肌酸激酶（CK）水平。采用Pearson相关性分析分析血清AngⅡ、TNF-α与心脏瓣膜置换术后患者心肌再灌注损伤指标（血清cTnT、CK）的相关性。结果　119例风湿性心脏病患者血清AngⅡ水平为（128.64±14.38）ng/dl，血清TNF-α水平为（38.67±4.52）fmol/ml，血清cTnT水平为（1.26±0.28）μg/L，血清CK水平为（267.52±10.54）U/L；Pearson相关性分析结果显示，血清AngⅡ、TNF-α与心脏瓣膜置换术后患者血清cTnT、CK水平均呈正相关（均r>0，P<0.05）。结论　血清AngⅡ、TNF-α水平与心脏瓣膜置换术后患者心肌再灌注损伤密切相关。

关键词: 风湿性心脏病, 心脏瓣膜置换术, 心肌再灌注损伤, 血管紧张素Ⅱ, 肿瘤坏死因子-α

Zhuang Yan. Correlations between serum angiotensin Ⅱ and tumor necrosis factor-α levels and myocardial reperfusion injury after heart valve replacement[J]. International Medicine and Health Guidance News, 2022, 28(16): 2320-2325.

庄严. 血清血管生成素Ⅱ和肿瘤坏死因子-α与心脏瓣膜置换术后心肌再灌注损伤的相关性[J]. 国际医药卫生导报, 2022, 28(16): 2320-2325.

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Correlations between serum angiotensin Ⅱ and tumor necrosis factor-α levels and myocardial reperfusion injury after heart valve replacement

血清血管生成素Ⅱ和肿瘤坏死因子-α与心脏瓣膜置换术后心肌再灌注损伤的相关性

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