Abstract: Objective　To explore the influencing factors of persistent cough in patients with non-small cell lung cancer after video-assisted thoracoscopic surgery (VATS). Methods　A total of 80 patients with non-small cell lung cancer treated in The First Affiliated Hospital of Henan University from June 2018 to December 2020 were selected as the research subjects, including 44 males and 36 females, aged (61.98±3.48) years. All patients were treated with VATS. The patients' persistent cough within 30 days after operation was observed and recorded, the patients were grouped, the patients' relevant data were recorded, the possible influencing factors were included, the baseline data questionnaire was designed, and the relevant factors that might lead to persistent cough after VATS in the patients with non-small cell lung cancer were analyzed. Independent sample t test was used for the measurement data, and χ² test was used for the count data. Results　Among the 80 patients with non-small cell lung cancer, 20 patients developed as persistent cough after VATS, with an incidence of 25.00%. The anesthesia time, endotracheal intubation time, and chest tube retention time in the occurrence group were (205.49±11.32) min, (5.49±0.89) d, and (8.62±2.45) d, which were longer than those in the non-occurrence group [(182.95±8.59) min, (3.53±0.59) d, and (5.37±1.67) d], and the proportions of lobectomy and peritracheal lymph node resection in the occurrence group were 65.00% (13/20) and 55.00% (11/20), which were higher than those in the non-occurrence group [30.00% (18/60) and 25.00% (15/60)], with statistically significant differences (all P<0.05). There were no statistically significant differences in the baseline data such as history of diabetes, pathological type, and pathological stage between the two groups (all P>0.05). Logistic regression analysis showed that long anesthesia time, lobectomy, peritracheal lymph node resection, long endotracheal intubation time, and long chest tube retention time were the influencing factors for the occurrence of persistent cough in the patients with non-small cell lung cancer after VATS (all OR>1, P<0.05). Conclusion　The occurrence of persistent cough in patients with non-small cell lung cancer after VATS is related to the factors such as long anesthesia time, lobectomy, peritracheal lymph node resection, long endotracheal intubation time, and long chest tube retention time.

Key words: Non-small cell lung cancer, Video-assisted thoracoscopic surgery, Persistent cough, Lobectomy

摘要： 目的　探究非小细胞肺癌患者电视辅助胸腔镜手术（VATS）后发生持续咳嗽的影响因素。方法　选取2018年6月至2020年12月河南大学第一附属医院收治的80例非小细胞肺癌手术患者作为研究对象，其中男44例、女36例，年龄（61.98±3.48）岁。观察并记录患者术后30 d内持续咳嗽发生状况并分组，询问并记录患者相关资料，将可能的影响因素纳入，设计基线资料调查表，分析可能导致非小细胞肺癌患者VATS术后发生持续咳嗽的相关因素。计量资料采用独立样本t检验，计数资料采用χ²检验。结果　80例非小细胞肺癌患者VATS术后有20例患者发生持续咳嗽，发生率为25.00%。发生组麻醉时间、气管插管时间、胸管留置时间分别为（205.49±11.32）min、（5.49±0.89）d、（8.62±2.45）d，均长于未发生组［（182.95±8.59）min、（3.53±0.59）d、（5.37±1.67）d］，发生组肺叶切除术、气管树周围淋巴结切除占比分别为65.00%（13/20）、55.00%（11/20），均高于未发生组［30.00%（18/60）、25.00%（15/60）］，差异均有统计学意义（均P<0.05）；两组糖尿病史、病理类型、病理分期等基线资料比较，差异均无统计学意义（均P>0.05）。logistic回归分析结果显示，麻醉时间长、肺叶切除、气管树周围淋巴结切除、气管插管时间长、胸管留置时间长是非小细胞肺癌患者VATS术后发生持续咳嗽的影响因素（均OR>1，P<0.05）。结论　非小细胞肺癌患者VATS术后发生持续咳嗽与麻醉时间长、肺叶切除、气管树周围淋巴结切除、气管插管时间长、胸管留置时间长等因素有关。

关键词: 非小细胞肺癌, 电视辅助胸腔镜手术, 持续咳嗽, 肺叶切除