Mechanism of action of microRNA-137 in gliomas

doi:10.3760/cma.j.issn.1007-1245.2022.13.029

Abstract

Abstract: MicroRNA-137 (miR-137) is abnormally expressed in many tumors, especially in gliomas. By targeting the regulation of CDK6, Rac1, MRGBP, Notch1, and other genes, as well as the signaling pathways mediated by PTP4A3 and FOXK1 genes, it participates in the proliferation, metabolism, cycle regulation, and invasion of glioma cells and patient prognosis. This paper focuses on several specific mechanisms of action of miR-137 in gliomas, so as to understand the potential functions of miR-137 and provide new ideas for the diagnosis and treatment of gliomas.

Key words: miR-137, Glioma, Targeted genes

摘要： microRNA-137（miR-137，微小RNA-137）在许多肿瘤中特别是神经胶质瘤中表达异常，其通过靶向调节CDK6、Rac1、MRGBP、Notch1等基因以及PTP4A3、FOXK1基因介导的信号通路参与神经胶质瘤细胞的增殖、代谢、周期调控、侵袭及患者预后。该文章重点讨论miR-137在神经胶质瘤中的几种特殊的作用机制，进一步了解了miR-137的潜在功能，为神经胶质瘤的诊疗提供新思路。

关键词: miR-137, 神经胶质瘤, 靶基因

Wang Ningning, Zhu Shuxia. Mechanism of action of microRNA-137 in gliomas[J]. International Medicine and Health Guidance News, 2022, 28(13): 1916-1919.

王宁宁朱淑霞. microRNA-137在神经胶质瘤中的作用机制[J]. 国际医药卫生导报, 2022, 28(13): 1916-1919.

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