Abstract: Objective　To explore the effect of Xipayi Mouth Rinse Fluid combined with minocycline on inflammatory factors in gingival crevicular fluid and periodontal clinical indicators in patients with periodontitis. Methods　Ninety-eight patients with periodontitis treated in Liaocheng No.4 People's Hospital from February 2019 to February 2022 were selected as the research objects, and they were divided into a control group and an observation group by the random number table method, with 49 cases in each group. The control group had 25 males and 24 females who were (43.73±3.58) years old, and were treated with minocycline. The observation group had 27 males and 22 females who were (44.43±4.76) years old, and were treated with Xipayi Mouth Rinse Fluid and minocycline. The clinical curative effects after the treatment, changes of inflammatory factors in gingival crevicular fluid, periodontal indicators before and after one course of treatment, and clinical safety were compared between the two groups. The independent-sample t test, paired t test, and χ² test were applied. Results　After the treatment, the total effective rate in the observation group was 95.92% (47/49), which was higher than that in the control group [79.59% (39/49)], with a statistical difference (χ²=6.078, P=0.014). After the treatment, the levels of interleukin -6(IL-6), monocyte chemoattractant protein (MCP-1), prostaglandin (PGE2), and visfatin (VF) in gingival crevicular fluid were (3.59±0.62) ng/L, (81.39±8.19) ng/L, (48.81±6.53) ng/L, and (31.41±7.56) μg/L in the observation group, and were (4.34±0.69) ng/L, (91.05±10.12) ng/L, (56.47±9.04) ng/L, and (40.58±6.53) μg/L in the control group, with statistical differences between the two groups (all P < 0.01). The periodontal probing depth (PD), attachment loss (AL), plaque index (PLI), and gingival sulcus bleeding index (SBI) were (3.02±0.56) mm, (2.08±0.49) mm, (1.12±0.33) points, and (1.18±0.39) points in the observation group, and were (3.69±0.87) mm, (2.69±0.72) mm, (1.82±0.44) points, and (2.08±0.45) points in the control group, with statistical differences between the two groups (all P < 0.01). The incidence of clinical adverse reactions was 4.08% (2/49) in the observation group, and was 10.20% (5/49) in the control group, with no statistical difference (χ²=1.427,P=0.232). Conclusion　Xipayi Mouth Rinse Fluid combined with minocycline can effectively relieve inflammation in periodontitis patients and improve their periodontal clinical indicators, and has good clinical effect.

Key words: Xipayi Mouth Rinse Fluid, Minocycline, Periodontitis, Inflammatory factors, Periodontal indicators

摘要： 目的　探究西帕依固龈液联合米诺环素对牙周炎患者龈沟液炎性因子水平及牙周临床指标的影响。方法　选取聊城市第四人民医院2019年2月至2022年2月收治的98例牙周炎患者作为研究对象，以随机数字表法分为两组，每组49例。对照组男25例、女24例，年龄（43.73±3.58）岁，给予米诺环素治疗；观察组男27例、女22例，年龄（44.43±4.76）岁，给予西帕依固龈液联合米诺环素治疗。比较两组患者治疗后的临床疗效，治疗前、治疗1个疗程后龈沟液炎性因子、牙周指标水平变化情况以及临床安全性。统计学方法采用独立样本t检验、配对t检验、χ²检验。结果　治疗后，观察组临床疗效总有效率为95.92%（47/49），高于对照组的79.59%（39/49），两组比较差异均有统计学意义（χ²=6.078，P=0.014）；治疗后，观察组的龈沟液炎性因子：白介素-6（IL-6）、单核细胞趋化蛋白（MCP-1）、前列腺素（PGE2）和内脂素（VF）水平分别为（3.59±0.62）ng/L、（81.39±8.19）ng/L、（48.81±6.53）ng/L、（31.41±7.56）μg/L，明显低于对照组的（4.34±0.69）ng/L、（91.05±10.12）ng/L、（56.47±9.04）ng/L、（40.58±6.53）μg/L，组间比较差异均有统计学意义（均P<0.001）；观察组牙周指标牙周探诊深度（PD）、附着丧失（AL）、菌斑指数（PLI）、龈沟出血指数（SBI）水平分别为（3.02±0.56）mm、（2.08±0.49）mm、（1.12±0.33）分、（1.18±0.39）分，显著低于对照组（3.69±0.87）mm、（2.69±0.72）mm、（1.82±0.44）分、（2.08±0.45）分，组间比较差异均有统计学意义（均P<0.001）。临床安全性对比，观察组临床不良反应总发生率略少于观察组［4.08%（2/49）比10.20%（5/49）］，两组比较差异无统计学意义（χ²=1.427，P=0.232）。结论　西帕依固龈液联合米诺环素能够有效缓解牙周炎患者炎症情况，改善牙周临床指标，具有良好的临床疗效。

关键词: 西帕依固龈液, 米诺环素, 牙周炎, 炎性因子, 牙周指标