Abstract:

Objective　To remind clinicians to pay attention to the superposition of adverse drug reactions when using combination drugs. Methods　This paper reports the data of 2 cases of liver injury caused by Gukang capsules combined with non-steroidal anti-inflammatory drugs. Literature review was conducted to analyze the correlation and pathogenesis of liver function injury caused by the drugs. Results　The liver function of the two patients returned to normal after withdrawal of Gukang capsules and non-steroidal drugs and treatment with hepatoprotective drugs. Both of them scored 7 points on the causality assessment form, and the correlation was judged as very likely. Conclusion　It is necessary to strengthen liver function monitoring and pay attention to the adverse reactions of liver injury when patients take Gukang capsules and non-steroidal anti-inflammatory drugs.

Key words: Drug-induced liver injury, Gukang capsules, Non-steroidal anti-inflammatory drugs, Adverse reactions

摘要： 目的　提醒临床医生联合用药时注意药物不良反应的叠加。方法　报道2例骨康胶囊合并非甾体类抗炎药后出现肝功能损伤的病例资料，查阅文献分析该药导致肝功能损伤的关联性和发病机制。结果　2例患者停用骨康胶囊及非甾体抗炎药物并给予保肝药物治疗后，肝功能均恢复正常。通过因果关系评估表评估得分均为7分，相关性判断为“很可能”。结论　患者使用骨康胶囊合并非甾体抗炎类药物时需加强肝功能监测，关注其肝损伤的不良反应。

关键词: 药物性肝损伤, 骨康胶囊, 非甾体抗炎药, 不良反应