Etiologic and epidemiologic characteristics of respiratory pathogenic
bacterial infection in 5 938 children from Changzhi City in Shanxi Province

doi:10.3760/cma.j.issn.1007-1245.2022.06.015

Abstract

Abstract: Objective　To investigate the epidemiological and etiological characteristics of respiratory tract infection in 5 938 children in Changzhi City of Shanxi province, and to provide scientific basis for the formulation of prevention strategies and clinical treatment for children. Methods　The samples of 5 938 hospitalized children with respiratory diseases in Changzhi Maternal and Child Health Hospital from December 2017 to February 2020 were collected, and 13 pathogenic bacteria were detected by loop mediated isothermal amplification technique (LAMP). χ² test was used for the count data, and Pearson correlation coefficient was used for correlation analysis. Results　Among the 5 938 cases, 3 394 (57.16%) were boys and 2 544 (42.84%) were girls, all ≤12 years old, with a total positive rate of 65.66% (3 899/5 938). The top three positive detection rates were 33.06% (1 963/5 938) of Streptococcus pneumoniae, 29.74% (1 766/5 938) of Haemophilus influenza, and 9.90% (588/5 938) of methicillin-resistant staphylococci. The detection rate of mixed infection was 25.60% (1 520/5 938), 2.73% (162/5 938) of severe pneumonia, 1.01% (60/5 938) of neonatal pneumonia, and 3.57% (212/5 938) of cerebrospinal fluid infection. Conclusions　Respiratory tract infection of children in Changzhi City of Shanxi Province is mainly caused by Haemophilus influenzae and Streptococcus pneumoniae. The composition of pathogenic bacteria varies with time, symptoms, sampling sites, population characteristics, and other factors, some of which have typical distribution characteristics.

Key words: Children, Respiratory tract infection, Pathogenic bacteria, Epidemiological characteristics

摘要： 目的　通过对5 938例呼吸道病原菌感染的儿童病例进行分析，为本地区患儿制定预防策略及临床治疗提供科学依据。方法　收集2017年12月至2020年2月期间长治市妇幼保健院5 938例患有呼吸道系统疾病的住院儿童标本，采用环介导恒温扩增技术（LAMP）对13种病原菌进行核酸检测。计数资料采用χ²检验，两组间相关性分析用Pearson相关系数。结果　5 938例患儿中，男孩3 394例（57.16%），女孩2 544例（42.84%），年龄均≤12岁，总阳性率为65.66%（3 899/5 938）。检出率前三位为肺炎链球菌33.06%（1 963/5 938）、流感嗜血杆菌29.74%（1 766/5 938）、耐甲氧西林葡萄球菌9.90%（588/5 938）。发现混合感染检出率为25.60%（1 520/5 938），重症肺炎检出率为2.73%（162/5 938），新生儿肺炎检出率为1.01%（60/5 938），脑脊液感染检出率为3.57%（212/5 938）。结论　儿童呼吸道系统感染主要是由流感嗜血杆菌和肺炎链球菌引起的，病原菌的检出构成随时间、症状、取样部位、人群特征等因素不同而变化，其中一些分布具有典型特征。

关键词: 儿童, 呼吸道感染, 病原菌, 流行病学特征

Feng Ruijie, Li Xiaoze. Etiologic and epidemiologic characteristics of respiratory pathogenic bacterial infection in 5 938 children from Changzhi City in Shanxi Province [J]. International Medicine and Health Guidance News, 2022, 28(6): 793-799.

冯睿杰, 李晓泽.

山西省长治市5 938例儿童呼吸道病原菌感染流行病学和病原学特征分析 [J]. 国际医药卫生导报, 2022, 28(6): 793-799.

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Etiologic and epidemiologic characteristics of respiratory pathogenic bacterial infection in 5 938 children from Changzhi City in Shanxi Province

山西省长治市5 938例儿童呼吸道病原菌感染流行病学和病原学特征分析

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